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ProteomicsBeyond self-resistance: ABCF ATPase LmrC is a signal-transducing component of an antibiotic-driven signaling cascade hastening the onset of lincomycin biosynthesis
In natural environments, antibiotics are an important instrument of inter-species competition. At subinhibitory concentrations, they act as cues or signals inducing antibiotic production: however, our knowledge of well-documented antibiotic-based sensing systems is limited. Here, for the soil actino...
ORGANISM(S): Streptomyces lincolnensis 
2021-08-18 | PXD026093 | Pride
Streptomyces lincolnensis Lmrc Resistance Lincomycin 
ProteomicsABCF Protein-Mediated Resistance Shapes Bacterial Responses Based on Antibiotic Type and Concentration
Antibiotic resistance (ARE) ABCF proteins are widespread, genome-encoded resistance factors in Gram-positive bacteria that rescue ribosomes stalled by antibiotics. In this study, we integrate genetic, proteomic, metabolomic, and biochemical approaches to reveal that ARE5 subfamily proteins, TiaA and...
ORGANISM(S): Streptomyces coelicolor 
2025-07-28 | PXD063714 | Pride
Streptomyces coelicolor Are acbf proteins Antibiotic resistance 
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