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TranscriptomicsAnalysis of the dose-dependent response of the ribosome-targeting antibiotic lincomycin on gene expression and its relationship to growth and secondary metabolism of S. coelicolor A3(2).
Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA of the 50S subunit of the bacterial ribosome, thereby inhibiting protein synthesis. We have previously reported that lincomycin at concentrations below the minimum inhibitory con...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2018-03-02 | E-MTAB-6434 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis exposed to red light illumination with and without lincomycin
To identify putative regulatory elements enriched in the promoters of target genes of the PGE-dependent retrograde signaling pathway, we analyzed 500 bp regions of sequence upstream of genes whose expression was down-regulated by lincomycin. We treated dark-grown Arabidopsis seedlings with lincomyci...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5759 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis col0,gun1,abi4-102, treated with and without lincomycin
To test the relationship between GUN1 and ABI4 Experiment Overall Design: 2*3 factorial design, two factors (1) treatment: with/without lincomycin (2) genotype: col0, gun1, abi4-102
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5770 | biostudies-arrayexpress
Transcriptomicsred illumination w/o lincomycin
To identify putative regulatory elements enriched in the promoters of target genes of the PGE-dependent retrograde signaling pathway, we analyzed 500 bp regions of sequence upstream of genes whose expression was down-regulated by lincomycin. We treated dark-grown Arabidopsis seedlings with lincomyci...
ORGANISM(S): Arabidopsis thaliana 
2006-09-06 | GSE5759 | GEO
TranscriptomicsLincomycin effect on PIFq-regulated transcriptome
RNA-seq experiment of WT and pifq mutant seedlings grown for 3 days in darkness in presence or absence of Lincomycin.
ORGANISM(S): Arabidopsis thaliana 
2016-03-08 | GSE78969 | GEO
ProteomicsBeyond self-resistance: ABCF ATPase LmrC is a signal-transducing component of an antibiotic-driven signaling cascade hastening the onset of lincomycin biosynthesis
In natural environments, antibiotics are an important instrument of inter-species competition. At subinhibitory concentrations, they act as cues or signals inducing antibiotic production: however, our knowledge of well-documented antibiotic-based sensing systems is limited. Here, for the soil actino...
ORGANISM(S): Streptomyces lincolnensis 
2021-08-18 | PXD026093 | Pride
Streptomyces lincolnensis Lmrc Resistance Lincomycin 
ProteomicsA systems biology-oriented investigation of Arabidopsis retrograde-signaling-defective mutant gun1 reveals the co-expression-based HUBs at the center of plastid development and homeostasis
In the present study we investigated at the system level the proteome obtained from seedlings of Arabidopsis thaliana wild-type Col-0 and gun1-101 and gun1-102 mutant plants treated or not with lincomycin (Lin), a chloroplast translation inhibitor widely used to inhibit chloroplast biogenesis and to...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-07-14 | PXD051970 | Pride
Gun1 Psbo Hub Lincomycin 
TranscriptomicsLight- and plastid-regulated transcriptomes in Arabidopsis seedlings
Plastids emit signals that broadly affect cellular processes. Based on previous genetic analyses, we propose that plastid signaling regulates the downstream components of a light signaling network and that these interactions coordinate chloroplast biogenesis with both the light environment and devel...
ORGANISM(S): Arabidopsis thaliana 
2012-03-02 | E-GEOD-24517 | biostudies-arrayexpress
UnknownSorption of Lincomycin by Manure-Derived Biochars from Water.
Not available
S-EPMC5896005 | biostudies-literature
UnknownMutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci.
Not available
S-EPMC2812159 | biostudies-literature
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