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ProteomicsNRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression
By precisely dissected LC-MS/MS for proteomics and phosphoproteomics, we found that deletion of NRBF2 disrupts neurogenesis-related protein network in the DG, such as neurogenesis, cell development, cell morphogenesis, cellular homeostasis, and synaptic plasticity.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD034382 | Pride
Autophagy Mouse Nrbf2 Dentate gyrus 
UnknownNRBF2-mediated autophagy contributes to metabolite replenishment and radioresistance in glioblastoma.
Not available
S-EPMC9723115 | biostudies-literature
UnknownNRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity.
Not available
S-EPMC4376476 | biostudies-literature
UnknownCell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression.
Not available
S-EPMC10465581 | biostudies-literature
UnknownNRBF2 regulates the chemoresistance of small cell lung cancer by interacting with the P62 protein in the autophagy process.
Not available
S-EPMC9194155 | biostudies-literature
UnknownNrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.
Not available
S-EPMC4176228 | biostudies-literature
UnknownNRBF2 homodimerization by its coiled-coil domain strengthens association with the PtdIns3K complex mediated by the MIT domain to promote autophagy.
Not available
S-EPMC12758336 | biostudies-literature
UnknownAutophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH.
Not available
S-EPMC8447596 | biostudies-literature
UnknownAutophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.
Not available
S-EPMC6882183 | biostudies-literature
UnknownNRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation.
Not available
S-EPMC8143228 | biostudies-literature
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