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ProteomicsProteomic and Phosphoproteomic Sequencing of NRK-49F Cells after TGF-β1 Stimulation: Impact of USP7 Knockout
Dysregulation of the expression of ubiquitin - specific protease 7 (USP7) has been associated with tumor progression. However, the biological functions and clinical significance of USP7 in renal fibrosis remain insufficiently explored. In this study, proteomic and phosphoproteomic sequencing were pe...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-07 | PXD059829 | Pride
Nrk-49f usp7 
MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
UnknownLefty-1 alleviates TGF-β1-induced fibroblast-myofibroblast transdifferentiation in NRK-49F cells.
Not available
S-EPMC4544629 | biostudies-literature
TranscriptomicsAcidosis activates the Nrf2-pathway in renal proximal tubule-derived cells through a crosstalk with renal fibroblasts
Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A former study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage. In order to gain further mechanistic insight into t...
ORGANISM(S): Rattus norvegicus 
2023-02-27 | GSE218626 | GEO
UnknownEpithelial-Fibroblast Crosstalk Protects against Acidosis-Induced Inflammatory and Fibrotic Alterations.
Not available
S-EPMC8945333 | biostudies-literature
UnknownAcidosis Activates the Nrf2 Pathway in Renal Proximal Tubule-Derived Cells through a Crosstalk with Renal Fibroblasts.
Not available
S-EPMC9952787 | biostudies-literature
UnknownCell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Not available
S-EPMC10691122 | biostudies-literature
GenomicsAcidosis activates the Nrf2-pathway in renal proximal tubule-derived cells through a crosstalk with renal fibroblasts
Acidosis activates the Nrf2-pathway in renal proximal tubule-derived cells through a crosstalk with renal fibroblasts
PRJNA904711 | ENA
UnknownKnockdown of lncRNA MALAT1 attenuates renal interstitial fibrosis through miR-124-3p/ITGB1 axis.
Not available
S-EPMC10593763 | biostudies-literature
UnknownYap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis.
Not available
S-EPMC6200934 | biostudies-literature
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