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TranscriptomicsComparison of Splenic Nrp1- and Nrp1+ Treg Populations
To compare subpopulations of Treg cells in wild type mice based upon Nrp1 Expression, differentiating nTreg and iTreg Cells were FACS sorted based upon expression of CD4, Foxp3 and expression of Nrp1.
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-40441 | biostudies-arrayexpress
GenomicsWildtype and NRP1 knockout macrophages
Wildtype and NRP1 knockout macrophages
PRJNA433729 | ENA
TranscriptomicsWB001A: Genome-wide analysis reveals NRP1 as a critical HIF1-E2F7 target gene in the regulation of motor neuron guidance in vivo
In this study, we explored the existence of a transcriptional network co-regulated by E2F7 and HIF1α, as we show that expression of E2F7, like HIF1α, is induced in hypoxia, and because of the previously reported ability of E2F7 to interact with HIF1α. Our genome-wide analysis uncovers a transcrip...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-66750 | biostudies-arrayexpress
ProteomicsImpaired AGO2/miR-185-3p/NRP1 Axis Promotes Colorectal Cancer Metastasis
Increasing evidence suggests that global downregulation of miRNA expression is a hallmark of human cancer, potentially due to defects in the miRNA processing machinery. In this study, we found that the protein expression of Argonaute 2 (AGO2), a key regulator of miRNA processing, was downregulated i...
ORGANISM(S): Homo Sapiens 
2021-02-11 | PXD024171 |
ProteomicsKCs with or without tamoxifen-triggered Nrp1 knockout and treated by HCM from premalignant hepatocytes
quantitative phosphoproteomic of KCs with or without tamoxifen triggered Nrp1 knockout and treated by HCM from premalignant hepatocytes
ORGANISM(S): Mus musculus (Mouse) 
2025-03-21 | PXD055381 | Pride
Mouse Kuffer premaligant 
TranscriptomicsPotentiation of regulatory T cell stability and function via a neuropilin-1:semaphorin-4a axis
Regulatory T cells (Treg) represent a critical immunoregulatory component of the immune system. The signals that maintain Treg stability and potentiate their function remain obscure. Here we show that the immune cell surface ligand semaphorin-4a (Sema4a) Sema treated and NRP1 knock outs were compare...
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-41185 | biostudies-arrayexpress
GenomicsBone Marrow Endothelial Cell Response to anti-NRP1 infusion
Bone Marrow Endothelial Cell Response to anti-NRP1 infusion
PRJNA630091 | ENA
TranscriptomicsTreg cells
This SuperSeries is composed of the following subset Series: GSE40441: Comparison of Splenic Nrp1- and Nrp1+ Treg Populations GSE40443: iTreg cells compared to WT Total Treg Refer to individual Series
ORGANISM(S): Mus musculus 
2012-08-30 | E-GEOD-40488 | biostudies-arrayexpress
TranscriptomicsRNAseq of HUVECs transfected with siRNA targeting Neuropilin 1 (NRP1) (si-NRP1) or a control non-targeting sequence (si-control) and exposed to unidirectional shear stress (20dyns/cm2), oscillatory flow (5dyn/cm2) or kept in absence of flow
HUVECs transfected with siRNA targeting Neuropilin 1(NRP1) (si-NRP1) or a control non-targeting sequence (si-control) and exposed to unidirectional shear stress (20dyns/cm2), oscillatory flow (5dyn/cm2) or kept in absence of flow.
ORGANISM(S): Homo sapiens 
2023-05-23 | E-MTAB-12191 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of the role of knocking down NRP1 after OGD/R in primary renal tubular epithelial cells
Neuropilin-1 (NRP1), a co-receptor for various cytokines, including TGF-β, has been identified as a potential therapeutic target for fibrosis. However, its role and mechanism in renal fibrosis remains elusive. Here, we show that NRP1 is upregulated in distal tubular (DT) cells of patients with trans...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-03 | PXD052244 | Pride
Lysine crotonylation Nrp1 Chronic kidney disease Acute kidney injury Aerobic metabolism 
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