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TranscriptomicsCompare gene expression profiles of mouse iNSC, WT-NSC, and MEF
The iNSC cells are two clones generated from the same MEF line. Therefore, we conducted one analysis that compared the two clonal lines and a separate analysis that compared iNSC vs. NSC, iNSC vs. MEF, and NSC vs. MEF. Both were single factor ANOVAs, the first compared two groups (the iNSC lines) ...
ORGANISM(S): Mus musculus 
2012-06-06 | E-GEOD-37859 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of MCF7 cells treated with NSC 59687 (Oxyphenisatin Acetate)
NSC 59687 (oxyphenisatin acetate) is a novel anti-cancer agent with selectivity for breast and ovarian cell lines To elucidate the transcripts differentially regulated following treatment with Oxyphenisatin acetate (NSC 59687) MCF7 cells were treated with 10 microM NSC 59687 for 24 hours followed by...
ORGANISM(S): Homo sapiens 
2013-03-13 | E-GEOD-45046 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of human iPSC-derived Neural Stem Cells (NSC) from LCA patients and unaffected persons
Our purpose was to investigate genes and molecular mechanisms involved in patients with Leber congenital amaurosis (LCA). Fibroblasts from two unrelated clinically-identified patients (Coriell) were reprogrammed to pluripotency by retroviral transduction. These human induced Pluripotent Stem Cells (...
ORGANISM(S): Homo sapiens 
2015-01-21 | E-GEOD-43924 | biostudies-arrayexpress
GenomicsMus musculus strain:NSC-34 cell line
Early transcriptomic responses to PGE2 and PGI2 in NSC-34 cells
PRJDB40580 | ENA
TranscriptomicsGene expression analysis of H9 hESC derived cardiomyocytes (CM) and neuron stem cells (NSC)
In this study, we generated wildtype H9 hESC derived cardiomyocytes (CM) and neural stem cells (NSC) by in vitro differentiation. Global gene expression profiles were compared among undifferentiated H9 hESC and the derived CM and NSC. Comparison of global gene expression profiles of undifferentiated...
ORGANISM(S): Homo sapiens 
2013-08-31 | E-GEOD-48257 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of H9 hESC derived neuron stem cells (NSC) harboring pathogenic LRRK2 (G2019S) mutation
Genetic mutations on leucine-rich repeat kinase 2 (LRRK2) have been associated with an increased risk of Parkinson's disease. The Gly2019Ser (G2019S) mutation on LRRK2 gene is a relatively common cause of familial Parkinson's disease in Caucasian population. In this study, we generated H9 hESC harbo...
ORGANISM(S): Homo sapiens 
2012-10-17 | E-GEOD-36321 | biostudies-arrayexpress
TranscriptomicsExpression profile of Ceacam1 downstream genes in NSC and NSCL61
To identify Ceacam1 downstream factors, we compared gene expressions between NSCs and Ceacam1L-expressing NSC and between NSCL61 and Ceacam1shRNA-expressing NSCL61. We established Ceacam1L-expressing NSC and Ceacam1shRNA-expressing NSCL61s. We think that genes, which are differently expressed betwee...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-70023 | biostudies-arrayexpress
GenomicsNSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice
NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice
PRJNA896873 | ENA
TranscriptomicsTranscription profiling of human MCF7 cells treated with ARC (NSC 188491)
ARC (NSC 188491, SMA-491), 4-amino-6-hydrazino-7-beta-d-ribofuranosyl-7H-pyrrolo-(2,3-d)-pyrimidine-5-carboxamide, is a nucleoside analog with profound in vitro anti-cancer activity. First identified in a high-throughput screen for inhibitors of p21 mRNA expression, subsequent experiments showed tha...
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-13477 | biostudies-arrayexpress
TranscriptomicsGenome wide analysis of RNA species present in SMN-containing RNPs
Several studies indicate that SMN-containing mRNP complexes could be involved in the axonal localization of a large number of mRNAs. We have used murine motor neuron-like NSC-34 cells and RNA Immuno-Precipitation experiments coupled to microarray analyses to perform a genome-wide analysis of RNA spe...
ORGANISM(S): Mus musculus 
2013-11-29 | E-GEOD-40197 | biostudies-arrayexpress
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