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ProteomicsRole of Nse1 subunit of SMC5/6 complex as a ubiquitin ligase
Structural Maintenance of Chromosomes (SMC) complexes - cohesin, condensin and SMC5/6 - are important for many aspects of the chromosomal organization. These complexes are composed of Smc and non-Smc element (Nse) subunits. The Nse1 subunit of SMC5/6 contains a variant RING domain, characteristic of...
ORGANISM(S): Homo sapiens (Human) Schizosaccharomyces pombe 927 
2022-01-24 | PXD029573 | Pride
Liquid chromatography Mass spectrometry Ubiquitination Smc5/6  nse1 Ubiquitin ligase 
ProteomicsUbiquitin proteomics reveals critical targets of the Nse1 RING domain in rDNA and genome stability
Ubiquitination controls most cellular processes, and its deregulation is associated to many pathologies. The Nse1 subunit in the Smc5/6 complex contains a RING domain with ubiquitin E3 ligase activity and important functions in genome integrity. However, Nse1-dependent ubiquitin targets remain large...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-05-05 | PXD028669 | Pride
Nse1 Ubiquitination 
UnknownRole of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase.
Not available
S-EPMC8750328 | biostudies-literature
UnknownNse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.
Not available
S-EPMC2555936 | biostudies-literature
UnknownStructure Basis for Shaping the Nse4 Protein by the Nse1 and Nse3 Dimer within the Smc5/6 Complex.
Not available
S-EPMC8173833 | biostudies-literature
UnknownCrucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression.
Not available
S-EPMC11335289 | biostudies-literature
UnknownA role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6.
Not available
S-EPMC7297730 | biostudies-literature
TranscriptomicsA transcriptomic analysis reveals increased complexity of the alternative splicing landscape by Nsmce1 overexpression in mouse hippocampal neuronal cell
Nsmce1 (NSE1 Homolog, SMC5-SMC6 Complex Component) is a Protein Coding gene, it was reported to function not only in positive regulation of response to DNA damage stimulus but also in the neurological diseases and disorders.
ORGANISM(S): Mus musculus 
2020-01-01 | GSE113436 | GEO
UnknownCryo-EM structure of the Smc5/6 holo-complex.
Not available
S-EPMC9458440 | biostudies-literature
Genomicssoil metagenome
Soil microbial communities from Maridalen valley, Oslo, Norway - NSE1 metagenome
PRJNA502720 | ENA
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