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ProteomicsN-terminal acetylome analyses reveals the substrate specificity profile of Naa50 (Nat5) and implicate NATs in influencing initiator Methionine processing
Co-translational N-terminal (Nt-) acetylation of nascent polypeptides is catalyzed by N-terminal acetyltransferases (NATs). The very N-terminal amino acid sequence is the major factor determining whether or not a given protein is Nt-acetylated. In humans, six different NATs, denoted NatA-NatF, are i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-05-29 | PXD001437 | Pride
N-terminal acetyltransferase / n-terminomics / nt-acetylome / naa50 / nate 
UnknownCRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation.
Not available
S-EPMC9741652 | biostudies-literature
UnknownSAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.
Not available
S-EPMC3725037 | biostudies-literature
UnknownMST1 promotes apoptosis through phosphorylation of histone H2AX.
Not available
S-EPMC2998151 | biostudies-literature
ProteomicsCRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation
N-degron pathway plays an important role in the protein quality control and maintenance of cellular protein homeostasis. ZER1 and ZYG11B, the substrate receptors of the Cullin 2-RING E3 ubiquitin ligase (CRL2), recognize N-terminal (Nt) glycine degrons and participate in the Nt-myristoylation qualit...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037312 | Pride
N-terminal acetylation Nt-ser Crl2zer1/zyg11b 
UnknownA novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ.
Not available
S-EPMC5022567 | biostudies-literature
UnknownDetection of Nα-terminally formylated native proteins by a pan-N-formyl methionine-specific antibody.
Not available
S-EPMC10164907 | biostudies-literature
Genomics
RNAPII Ser-2P CUT&Tag assay following osmotic stress and MLN4924 treatment
PRJNA1178728 | ENA
UnknownThe human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4.
Not available
S-EPMC3174195 | biostudies-literature
UnknownNovel human cell expression method reveals the role and prevalence of posttranslational modification in nonmuscle tropomyosins.
Not available
S-EPMC8463859 | biostudies-literature
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