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ProteomicsQKI dysregulation induces extensive splicing changes in T-cell acute lymphoblastic leukemia
Understanding the molecular mechanisms underlying T-cell acute lymphoblastic leukemia (T-ALL) is essential for developing more effective therapeutic strategies. Despite advancements in T-ALL treatment, the role of RNA-binding proteins in the disease pathogenesis remains poorly understood. Here, we i...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD058761 | Pride
Human Splicing T-all 
GenomicsNotch1-driven epigenetic changes in a mouse model of T cell Acute Lymphoblastic Leukemia (T-ALL)
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we used a mouse model of T-ALL through the overexpression of the intarcellular transcriptionally active part of Notch1 (N1-IC). This model fait...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-34954 | biostudies-arrayexpress
TranscriptomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [short_hairpins_RNA-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we abrogated the expression of JMJD3 (KDM6B) and UTX (KDM6A) H3K27me3 demethylases in human T-ALL lines and assayed for genome-wide expression ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56689 | biostudies-arrayexpress
GenomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [GSKJ4_ChIP-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we chemically inhibited the H3K27me3 demethylase JMJD3 using the GSKJ4 inhibitor and assayed for genome-wide changes in H3K27me3 and JMJD3 enri...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56693 | biostudies-arrayexpress
GenomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [JMJD3_CUTLL1_ChIP-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we assayed for genome-wide localization of JMJD3 enrichment. This piece of data was further integrated to expression changes using RNA sequenci...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56694 | biostudies-arrayexpress
GenomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [shJMJD3_ChIP-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we abrogated the expression of JMJD3 (KDM6B) and UTX (KDM6A) H3K27me3 demethylases in human T-ALL lines and assayed for genome-wide changes in ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56692 | biostudies-arrayexpress
TranscriptomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [UTXKO_RNA-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we conduct expression analysis in NOTCH1-IC-induced tumors in Utx wild-type (Utx+/+ or Utx+/Y) and knockout (Utx-/Y) background. These results,...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-56690 | biostudies-arrayexpress
TranscriptomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [GSKJ4_RNA-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we chemically inhibited the H3K27me3 demethylase JMJD3 using the GSKJ4 inhibitor and assayed for genome-wide changes in H3K27me3 and JMJD3 enri...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56691 | biostudies-arrayexpress
TranscriptomicsNotch1-driven transcriptional changes in a mouse model of T-ALL
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we used a mouse model of T-ALL through the overexpression of the intarcellular transcriptionally active part of Notch1 (N1-IC). This model fait...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-34554 | biostudies-arrayexpress
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