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TranscriptomicsTranscription profiling of human CALM-AF10 positive and negative T-ALL samples
Comparison of a series of 6 CALM-AF10 positive T-ALL to a series of 17 CALM-AF10 negative T-ALL
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2117 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile of 53 human T-ALL samples collected in human clinical trial E2993 (Marks et al., 2009)
To analyze the prognostic relevance of transcriptional profiling in adult T-ALL, we analyzed a clinical series of 53 primary leukemia samples uniformly treated according to the ECOG E2993 protocol using gene expression oligonucleotide microarrays. Unsupervised analysis and consensus clustering of mi...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-42328 | biostudies-arrayexpress
GenomicsNotch1-driven epigenetic changes in a mouse model of T cell Acute Lymphoblastic Leukemia (T-ALL)
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we used a mouse model of T-ALL through the overexpression of the intarcellular transcriptionally active part of Notch1 (N1-IC). This model fait...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-34954 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T-ALL patients at diagnosis and relapse
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 104 samples; Affymetrix U133A micro-arrays.

Ninety two patients with T-ALL were diagnosed and treated at Saint-Louis hospital, Paris. Seven patients were studied a...
ORGANISM(S): Homo sapiens 
2005-04-15 | E-MEXP-313 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures of 64 T-ALL patient samples
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62131 | biostudies-arrayexpress
GenomicsHomo sapiens strain:T-ALL
Homo sapiens strain:T-ALL Raw sequence reads
PRJNA897746 | ENA
TranscriptomicsExpression profiling of mouse T-ALL (Vav-tTA;TRE-GFP-shIkaros primary leukemia ALL101) cells following Ikaros restoration [RNA-Seq]
To examine Ikaros tumor suppressor mechanisms, we have utilized inducible RNAi to dynamically restore endogenous Ikaros expression in T-ALL driven by its knockdown. This causes rapid transcriptional repression of Notch1 and associated targets including Myc, even in leukemias harboring spontaneous ac...
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-54447 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile of 57 human T-ALL samples collected in human clinical trial E2993 (Marks et al., 2009)
Analysis of microarray gene expression signatures in adult T-ALL demonstrated a high prevalence of early immature leukemias and revealed a close relationship between these tumors and myeloid leukemias. 57 adult T-ALL samples were analyzed
ORGANISM(S): Homo sapiens 
2011-11-05 | E-GEOD-33469 | biostudies-arrayexpress
TranscriptomicsGene expression data of diagnostic childhood T-ALL samples and human thymocytes
Lymphotoxin-mediated activation of the lymphotoxin-β receptor (LTβR) has been implicated in several physiological and pathological processes, including lymphoid organ development, T-cell maturation, and solid and hematopoietic malignancies. Its role in T-cell acute lymphoblastic leukemia (T-ALL) o...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-66638 | biostudies-arrayexpress
TranscriptomicsSmall RNA-Seq Reveals similar miRNA Transcriptome in Children and Young Adults with T-ALL and Indicates miR-143-3p as Novel Candidate Tumor Suppressor in This Leukemia
We aimed to identify miRNAs and pathways specifically deregulated in adolescent and young adult (AYA) T-ALL patients. Small RNA-seq showed no major differences between AYA and pediatric T-ALL, but it revealed downregulation of miR-143-3p in T-ALL patients. Prediction algorithms identified several kn...
ORGANISM(S): Homo sapiens 
2022-09-06 | E-MTAB-11987 | biostudies-arrayexpress
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