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ProteomicsRanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion
Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes called annulate lamellae (AL). Though discovered in the mid-20th century, AL’s function and biogenesis re...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD073946 | Pride
Nuclear expansion Climp63 (ckap4) G1 Single molecule localization microscopy (smlm) Annulate lamellae Nuclear growth Fg repeats Ranbp2 (nup358) Nuclear pore complex Cytoplasmic nucleoporin foci 
ProteomicsComparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope
The nuclear envelope (NE) is a subdomain of the ER with a distinctive protein composition that underpins its role in nuclear compartmentalization. To expand an understanding of NE functions, we refined methods to reveal low abundance transmembrane (TM) proteins concentrated at the NE. De facto, th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-25 | MSV000091154 | MassIVE
GenomicsNuclear expansion drives chromatin structure remodeling in aging neurons
Nuclear expansion drives chromatin structure remodeling in aging neurons
PRJNA1126648 | ENA
TranscriptomicsNkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors
Loss of functional beta-cell mass is a hallmark of Type 1 and Type 2 diabetes, and methods for restoring these cells are needed. We have previously reported that overexpression of the homeodomain transcription factor Nkx6.1 in rat pancreatic islets induces beta-cell proliferation and enhances glucos...
ORGANISM(S): Rattus norvegicus 
2014-02-18 | E-GEOD-55077 | biostudies-arrayexpress
GenomicsNuclear GSK-3β and Oncogenic KRas Promote Aqp5+ Pancreatic Duct Stem Cell Expansion
Nuclear GSK-3β and Oncogenic KRas Promote Aqp5+ Pancreatic Duct Stem Cell Expansion
PRJNA717225 | ENA
GenomicsIn vitro expansion of human sperm through nuclear transfer
In vitro expansion of human sperm through nuclear transfer
PRJNA527293 | ENA
TranscriptomicsTranscription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP98-HOX Fusion Genes
BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9079 | biostudies-arrayexpress
UnknownNuclear envelope expansion in budding yeast is independent of cell growth and does not determine nuclear volume.
Not available
S-EPMC6337908 | biostudies-literature
TranscriptomicsRegulation of the ESC transcriptome by nuclear long non-coding RNAs
We performed poly(A)+ RNA sequencing (Illumina GAIIx) from nuclear and whole cell RNA fractions of mouse AB2.2 embryonic stem cells (ESCs) and neural progenitors (NPCs) differentiated from ESCs. We further transfected AB2.2 ESCs with control antisense oligonucleotides (ASOs), or 2 independent ASOs e...
ORGANISM(S): Mus musculus 
2015-12-01 | E-MTAB-3198 | biostudies-arrayexpress
TranscriptomicsHuman-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
The evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Here, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a novel approach from developi...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-65000 | biostudies-arrayexpress
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