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TranscriptomicsFormalin Fixation at Low Temperature Better Preserves Nucleic Acid Integrity
INTRODUCTION. Fixation with formalin, a widely adopted procedure to preserve tissue samples, leads to extensive degradation of nucleic acids and thereby compromises procedures like microarray-based gene expression profiling. We hypothesized that RNA fragmentation is caused by activation of RNAses du...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-27175 | biostudies-arrayexpress
GenomicsSubmission of Nucleic Acid Sequences
Nucleic Acid Sequence Submission
PRJEB103858 | ENA
MetabolomicsMetabolomic analysis on Microcystis aeruginosa cells under various amino acid supplementation conditions
Threonine, an essential amino acid for translation, exhibits toxicity towards slow-growing cyanobacteria. This prompted us to perform transcriptomic and proteomic analyses using Microcystis aeruginosa cells treated with threonine, revealing a noteworthy upregulation of thrC, annotated as pyridoxal 5...
2025-04-02 | MTBLS11852 | MetaboLights
UnknownMultifunctional nucleic acids for tumor cell treatment.
Not available
S-EPMC3962646 | biostudies-literature
MetabolomicsProteomics and metabolomics analysis based on exosomes revealed the response mechanism of Alicyclobacillus acidoterrestris to acid stress

Bacteria secrete exosomes containing stress-related molecules such as proteins and nucleic acids, which facilitate adaptation to challenging environments. In order to elucidate the role of A. acidoterrestris exosomes in its acid stress response, this study combined proteomics and metabolomics to ...

2025-09-13 | MTBLS12995 | MetaboLights
MetabolomicsProteomics and metabolomics analysis based on exosomes revealed the response mechanism of Alicyclobacillus acidoterrestris to acid stress

Bacteria secrete exosomes containing stress-related molecules such as proteins and nucleic acids, which facilitate adaptation to challenging environments. In order to elucidate the role of A. acidoterrestris exosomes in its acid stress response, this study combined proteomics and metabolomics to ...

2025-09-14 | MTBLS12996 | MetaboLights
UnknownExperimental Model Systems Used in the Preclinical Development of Nucleic Acid Therapeutics.
Not available
S-EPMC10457615 | biostudies-literature
ProteomicsIdentifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics
Background: The intracellular pathogen Mycobacterium tuberculosis is known to encounter several stress conditions during infection, including low pH, hypoxia, starvation and oxidative and nitrosative stress. Mycobacterial adaptation to stress conditions is, in part, mediated by several nucleic acid-...
ORGANISM(S): Mycobacterium smegmatis Bacteria 
2020-03-05 | PXD016241 | Pride
Nucleic acid-associated proteins Affinity-purification Mycobacterium Rna polymerase 
ProteomicsProteomics analysis of cellular nucleic acid binding proteins
Organic solvents and Ti4+-IMAC capture of formaldehyde (FA) cross-linked cells followed by mass spectrometry analysis to identify nucleic acid binding proteins in human cells.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD026035 | Pride
Nucleic acid binding protemoics Lc/ms-ms Human lung cancer 
UnknownThermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides.
Not available
S-EPMC2965255 | biostudies-literature
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