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GenomicsVirulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein
The principal virulence determinant of Mycobacterium tuberculosis (Mtb), the ESX-1 protein secretion system, is positively controlled at the transcriptional level by EspR. Depletion of EspR reportedly affects a small number of genes, both positively or negatively, including a key ESX-1 component, th...
ORGANISM(S): Mycobacterium tuberculosis 
2012-04-02 | E-GEOD-35149 | biostudies-arrayexpress
MetabolomicsMuscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α) is posi...

2025-04-09 | MTBLS914 | MetaboLights
MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
ProteomicsData on nucleoid-associated proteins isolated from Mycoplasma gallisepticum after intracellular infection
Mycoplasma gallisepticum belongs to the class Mollicutes. It causes chronic respiratory disease in avian species. M. gallisepticum is characterized by lack of cell wall; reduced genome size and the volume of its nucleoid is comparable to the size of the whole cell. As a result of genome reduction, M...
ORGANISM(S): Mycoplasma gallisepticum S6 
2021-03-31 | PXD025107 | Pride
Mycoplasma gallisepticum Shotgun proteomics Intracellular infection Lc-ms/ms Nucleoid-associated peoteins 
TranscriptomicsThe nucleoid-associated protein HU controls three regulons that coordinate virulence and general physiology in Salmonella enterica serovar Typhimurium
The regulon of genes controlled by the HU nucleoid-associated proteins was examined in Salmonella enterica serovar Typhimurium (S. Typhimurium). DNA microarrays were used to detect the effect on the bacterial transcriptome of knockout mutations in the hupA, the hupB and in both the hupA and hupB gen...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2011-03-22 | E-GEOD-22860 | biostudies-arrayexpress
ProteomicsProteomic profile of nucleoid-associated proteins isolated from Mycoplasma gallisepticum in different growth phases
Mycoplasma gallisepticum (MG) is one of the smallest free-living and self-replicating organisms, it is characterized by lack of cell wall and reduced genome size. As a result of genome reduction, MG has a limited variety of DNA-binding proteins (DBP) and transcription factors. To investigate the dyn...
ORGANISM(S): Mycoplasma gallisepticum S6 
2020-05-12 | PXD019077 | Pride
Mycoplasma gallisepticum Synchronous growth Dia Nucleoid Nucleoid associated proteins 
GenomicsSystems-wide analysis of the GATC-binding nucleoid-associated protein Gbn and its impact on Streptomyces development
Systems-wide analysis of the GATC-binding nucleoid-associated protein Gbn and its impact on Streptomyces development
PRJNA697922 | ENA
ProteomicsProteins co-purified with nucleoid-associated proteins in Burkholderia cenocepacia H111
In this project, we aimed at identifying H-NS proteins co-purified with two nucleoid-associated proteins (NAPs) in Burkholderia cenocepacia H111 under standard growth conditions. We created strains expressing FLAG-tagged NAPs in addition to the untagged proteins, carried out co-immunoprecipitation e...
ORGANISM(S): Burkholderia cenocepacia H111 Bacteria 
2026-07-21 | PXD070299 | Pride
Nucleoid-associated protein Burkholderia cenocepacia H-ns 
GenomicsIPOD-HR, ChIP-seq, RNA-seq of E. coli nucleoid associated protein deletions
IPOD-HR, ChIP-seq, RNA-seq of E. coli nucleoid associated protein deletions
PRJNA691963 | ENA
TranscriptomicsChIP-chip of HA-tagged Lsr2 in Mycobacterium tuberculosis and Mycobacterium smegmatis
Bacterial nucleoid-associated proteins play important roles in chromosome organization and global gene regulation. We find that Lsr2 of Mycobacterium tuberculosis is a novel nucleoid-associated protein that specifically binds AT-rich regions of the genome, including regions encoding major virulence ...
ORGANISM(S): Mycobacterium smegmatis 
2010-06-19 | E-GEOD-18652 | biostudies-arrayexpress
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