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MetabolomicsNucleotide depletion signals early-stage soil stable carbon collapse in anthropogenically disturbed alpine ecosystems
Anthropogenic disturbances are a primary cause of soil organic carbon (SOC) destabilization in alpine ecosystems. However, effective management is hindered by a """"response delay"""" of macro metrics used to characterize stable carbon pools (e.g., microbial necromass carbon and aggregate associated...
2026-05-23 | MTBLS14572 | MetaboLights
MetabolomicsAn overlooked prebiotic: beneficial effect of dietary nucleotide supplementation on gut microbiota and metabolites in senescence-accelerated mouse prone-8 mice
Nucleotides (NTs) are regulatory factors in many biological processes and play important roles in the growth, development, and metabolism of living organisms. We used senescence-accelerated mouse prone-8 (SAMP8) to investigate the effects of NTs on the gut microbiota and metabolites. And the promoti...
2022-03-21 | MTBLS4012 | MetaboLights
MetabolomicsMulti-omic Profiling of Multi-Biosamples Reveals the Role of Amino Acid and Nucleotide Metabolism in Endometrial Cancer
Endometrial cancer (EC) is one of the most common gynecological cancers. Finding biomarkers of EC can support its diagnosis in a non- or minimally-invasive way. In this work, we integrated metabolomics and proteomics for the analysis of multiple types of biosamples to gain a more comprehensive view ...
2022-03-28 | MTBLS3935 | MetaboLights
MetabolomicsUntargeted metabolomics reveals bovine viral diarrhea virus infection reprogram host nucleotide and amino acid metabolism in MDBK Cells

Bovine viral diarrhea virus (BVDV) is a highly adapted intracellular parasite that depends entirely on the host cell's metabolic resources and energy for the synthesis of viral components. However, the mechanisms by which BVDV remodels host lipid metabolism remain unclear. In this study, we explo...

2025-10-12 | MTBLS13126 | MetaboLights
ProteomicsLaboratory evolution in Novosphingobium aromaticivorans enables rapid catabolism of a model lignin-derived aromatic dimer
Lignin contains a variety of interunit linkages, which leads to a range of potential decomposition products that can be used as carbon and energy sources by microbes. B-O-4 linkages are the most common in native lignin and associated catabolic pathways have been well characterized. However, the fate...
ORGANISM(S): Novosphingobium Aromaticivorans (ncbitaxon:48935) 
2024-08-29 | MSV000095729 | MassIVE
GenomicsEndoplasmic Reticulum Stress-Driven Nucleotide Catabolism Fuels Prostate Cancer
Endoplasmic Reticulum Stress-Driven Nucleotide Catabolism Fuels Prostate Cancer
PRJNA1287778 | ENA
UnknownInitiation of cytosolic plant purine nucleotide catabolism involves a monospecific xanthosine monophosphate phosphatase.
Not available
S-EPMC8616923 | biostudies-literature
UnknownHorizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis.
Not available
S-EPMC6904512 | biostudies-literature
TranscriptomicsIncreased Neanderthal ancestry in genomic regions associated with lipid catabolism in contemporary Europeans
While Neanderthals are extinct, fragments of their genome still persist in the genomes of contemporary humans. Here, we show that such Neanderthal-like sequences are not distributed randomly in contemporary human genomes. Specifically, while genome-wide frequency of Neanderthal-like sites is close t...
ORGANISM(S): human 
2014-03-31 | E-GEOD-45263 | biostudies-arrayexpress
UnknownA plastid carbohydrate carrier mediates ribose recycling from nucleotide catabolism and glucose export from starch degradation.
Not available
S-EPMC12589546 | biostudies-literature
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