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GenomicsGenome-wide maps of Nup98 binding in human embryonic stem cells, neural progenitors, neuron cells and lung fibroblasts
Recent evidence suggests that nucleoporins, well known components that control nucleo-cytoplasmic trafficking, have wide-ranging functions in developmental gene regulation that potentially extend beyond their role in nuclear transport. Whether the unexpected role of nuclear pore proteins in transcri...
ORGANISM(S): Homo sapiens 
2013-07-17 | E-GEOD-48996 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NUP98-NSD1 transformed samples reveals NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. INCOMPLETE DATASET
Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that are essential in development and are mutated in human acute myeloid leukemia (AML), overgrowth syndromes, multiple myeloma and lung cancers. ...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10071 | biostudies-arrayexpress
GenomicsGenome wide localization of chromatin bound NUP98-PHF23 (NP23)
We analyzed the genome wide localization of H3K4me3, H3K27me3 and the NUP98-PHF23 (with V5 tag) fusion protein which binds H3K4me3 via its PHD finger, using ChIP-seq. Results correlated with gene expression profiles. NUP98-PHF23 bound only 1.6% of H3K4me3 marks including Hoxa/b + Meis1. Assess H3K4m...
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-54786 | biostudies-arrayexpress
Transcriptomicstranscriptional profiling of NUP98-CDX1, NUP98-CDX4 and EGFP overexpressing primitive mouse bone marrow cells
The first genetic hits towards leukemia are thought often to confer to the mutant clone a slight proliferative/survial advantage. These pre-malignant clones can then be maintained under physiological cues in normal pool for long periods. We have searched for this type of first genetic hits and found...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-37900 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP98-HOX Fusion Genes
BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9079 | biostudies-arrayexpress
TranscriptomicsGene expression study of leukemic and premalignant hematopoietic tissues from NUP98-PHF23 (NP23) mice.
NUP98-PHF23 is oncogenic and results in a Hoxa/b + Meis1 overexpression in NP23 leukemias and in premalignant (clinically healthy) hematopoietic tissues. Gene expression profiles from AML, pre-T LBL and B-ALL were compared to wild type bone marrow, thymus and spleen tissues respectively. Similarly, ...
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-54787 | biostudies-arrayexpress
TranscriptomicsExpression data from murine hematopoietic cells expressing BCR-ABL alone, NUP98-HOXA9 alone, BCR-ABL and NUP98-HOXA9, or null for both oncogenes
Leukemia is a complex malignancy with hundreds of distinct mutations associated with disease development. Studies have shown that oncogenes cooperate to promote leukemia transformation, however, the downstream effectors of this cooperation are largely unknown. Using a genetically defined mouse mode...
ORGANISM(S): Mus musculus 
2012-05-10 | E-GEOD-37907 | biostudies-arrayexpress
GenomicsNUP98-PHF23
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-54788 | biostudies-arrayexpress
TranscriptomicsTransgenic NUP98-HOXA9 Zebrafish Embryos: Unactivated ('lGl') vs. Cre-activated ('NHA9')
Transcriptional profiling of zebrafish embryos at 28 hours post fertilization, comparing control 'unactivated' Tg(spi1::lox-eGFP-lox::NHA9) embryos with experimental 'Cre-activated' Tg(spi1::NHA9) embryos. Goal was to determine the effects of expressing NUP98-HOXA9 oncogene on global and blood cell-...
ORGANISM(S): Danio rerio 
2014-10-30 | E-GEOD-62793 | biostudies-arrayexpress
ProteomicsNUP98-NSD1 its mutated forms interactome
Interactome studies of NUP98-NSD1 and its mutated forms in HEK293 cells
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026020 | Pride
Aml Smarca5 Interactome Phase separation 
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