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ProteomicsHuman SMARCA5 interactome in transgenic SMARCA5 mouse model
We hypothesize that the ISWI ATPase Smarca5 plays a role in hematopoietic stem cell development via its interaction partners, and to study the role, we used a mouse model with transgenic expression of SMARCA5 coupled with mass spectrometry analysis. The study uses transgenic SMARCA5 mouse model with...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-22 | PXD049034 | Pride
Smarca5 Transgenic mice Immunoprecipitation 
ProteomicsSpatiotemporal control of SMARCA5 by a MAPK-RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration
Acute pancreatitis-induced acinar-to-ductal metaplasia (ADM) involves global chromatin remodeling and contributes to normal tissue regeneration. Oncogenic KRAS hijacks this process to promote PDAC formation. Here we show that regeneration and KRASG12D-driven oncogenesis can be decoupled from tissue ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-23 | PXD047272 | Pride
Mousee smarca5 pdac 
ProteomicsDifferential requirements for Smarca5 expression during hematopoietic stem cell commitment.
The formation of hematopoietic cells relies on the chromatin remodeling activities of ISWI ATPase SMARCA5 (SNF2H) and its complexes. The Smarca5 null and conditional alleles have been used to study its functions in embryonic and organ development in mice. These mouse model phenotypes vary from embry...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-10-27 | PXD048865 | panorama
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [RNA-seq]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [RNA-seq]
PRJNA673230 | ENA
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [CUT&RUN]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [CUT&RUN]
PRJNA673248 | ENA
UnknownHuman SMARCA5 is continuously required to maintain nucleosome spacing.
Not available
S-EPMC9974918 | biostudies-literature
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [ATAC-seq]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [ATAC-seq]
PRJNA673249 | ENA
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [PRO-seq]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [PRO-seq]
PRJNA673231 | ENA
GenomicsSMARCA5 links histone lactylation to metabolic reprogramming and immune evasion
SMARCA5 links histone lactylation to metabolic reprogramming and immune evasion
PRJNA1307576 | ENA
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [MNAse-Seq]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [MNAse-Seq]
PRJNA911309 | ENA
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