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MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
MetabolomicsHost autophagy mediates organ wasting and nutrient mobilization for tumor growth
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through ...
2021-09-24 | MTBLS2771 | MetaboLights
MetabolomicsBacterial extracellular vesicles as recyclable nutrient reservoirs

Bacterial extracellular vesicles (EVs) are known to mediate intercellular communication, virulence, and immune modulation. Here we show that bacteria can utilise EVs also as recyclable nutrient reservoirs. Using Bacillus cereus as a model organism, we demonstrate that EVs exhibit distin...

2026-02-18 | MTBLS13260 | MetaboLights
MetabolomicsMulti-Omics Reveals that Alkaline Mineral Complex Enhances Nutrient Digestion–Absorption and Gut Health

This study, conducted under a high-concentrate finishing context, used an integrated multi-omics approach to evaluate the effects of an Alkaline Mineral Complex (AMC) on jejunal digestion–absorption and gut health in beef cattle. The results showed that AMC alleviated mucosal pathological injury ...

2026-07-14 | MTBLS13175 | MetaboLights
MetabolomicsBacteria encode their own post-mortem protein catabolism to enable nutrient recycling
For many organisms, death is a tangible, visible event. In bacteria, death can be a natural or an induced process 1. Death permits genes conferring a survival advantage to be selected in a bacterial population. Furthermore, biomolecule recycling from dead bacteria is crucial under nutrient limitatio...
2025-01-23 | MTBLS10044 | MetaboLights
MetabolomicsInositol polyphosphates regulate resilient mechanisms in the green alga Chlamydomonas reinhardtii to adapt to extreme nutrient conditions

In the actual context of climate changing environments, photosynthetic organisms need to adapt to more extreme conditions. Microalgae can be excellent organisms to understand molecular mechanisms that activate survival mechanisms under stress. Chlamydomonas reinhardtii signaling mutants are extre...

2024-12-05 | MTBLS10779 | MetaboLights
MetabolomicsGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SL...

2022-09-20 | MTBLS4268 | MetaboLights
MetabolomicsNutrient environment drives strain-specific remodelling of Escherichia coli lipidomes
Background/Objectives: Escherichia coli causes more than 2.8 million infections annually and is widely used as a model organism. Despite its importance, strain-level and handling differences in E. coli lipidomes remain poorly defined. Lipid composition can reveal membrane organization, metabolic sta...
2026-09-23 | MTBLS14565 | MetaboLights
MetabolomicsLimited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells, a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables the adaptation to these co...

2022-04-29 | MTBLS4722 | MetaboLights
MetabolomicsOGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

Acute Myeloid Leukemia (AML) commonly relapses after initial chemotherapy response. We assessed metabolic adaptations in chemoresistant cells in vivo before overt relapse, identifying altered branched-chain amino acid (BCAA) levels in patient-derived xenografts (PDX) and immunophenotypically iden...

2025-07-19 | MTBLS10255 | MetaboLights
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