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UnknownEffect of amitriptyline on symptoms in treatment naive patients with interstitial cystitis/painful bladder syndrome.

Purpose

Amitriptyline is frequently used to treat patients with interstitial cystitis/painful bladder syndrome. The evidence to support this practice is derived mainly from a small, single site clinical trial and case reports.

Materials and methods

We conducted a multicenter, randomiz...
S-EPMC2861998 | biostudies-literature
UnknownGenome-wide association study identifies five loci associated with lung function.
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta conso...
S-EPMC2862965 | biostudies-literature
UnknownNew genetic loci link adipose and insulin biology to body fat distribution.
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide asso...
S-EPMC4338562 | biostudies-literature
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