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GenomicsDetermining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study)

CHD is the leading cause of death in the United States. One of the most common ways to prevent CHD is to take an anti-platelet agent, which lessens platelet aggregation. Two of the most common anti-platelet agents are aspirin and clopidogrel. However, up to 25% to 30% of people do not r...

phs000391.v1.p1 | EGA
UnknownParaoxonase 1 (PON1) gene variants are not associated with clopidogrel response.
Not available
S-EPMC3250350 | biostudies-literature
UnknownThe functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
Not available
S-EPMC3682407 | biostudies-literature
UnknownAssociation of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
Not available
S-EPMC3641569 | biostudies-literature
UnknownGenetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.
Not available
S-EPMC3715320 | biostudies-literature
ProteomicsUpregulation of USP18-ISG15 axis associates with protective immune responses and limited histopathology during SARS-CoV2 infection of the human lung
Investigating the intra-lung human immune responses to SARS-CoV-2, and how immune signatures temporally correlate to distinct histopathological manifestations of disease in the human lung, is not possible in human patients. While current non-human primate and rodent models have proven instrumental f...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-04-14 | PXD025851 | Pride
Lung fetal xenograft Humanized mice Sars-cov-2 Covid19 
UnknownBCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial.
Not available
S-EPMC11409612 | biostudies-literature
UnknownHumanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection.
Not available
S-EPMC8977517 | biostudies-literature
UnknownThe Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.
Not available
S-EPMC11244923 | biostudies-literature
UnknownStatin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials.
Not available
S-EPMC7903384 | biostudies-literature
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