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TranscriptomicsQuality Control in Microarray Assessment of Gene Expression in Human Airway Epithelium
Microarray technology provides a powerful tool for defining gene expression profiles of airway epithelium that lend insight into the pathogenesis of human airway disorders. The focus of this study was to establish rigorous quality control parameters to ensure that microarray assessment of the airway...
ORGANISM(S): Homo sapiens 
2010-09-19 | E-GEOD-11906 | biostudies-arrayexpress
TranscriptomicsDisparate Oxidant-related Gene Expression of Human Small Airway Epithelium Compared to Autologous Alveolar Macrophages
Disparate Oxidant-related Gene Expression of Human Small Airway Epithelium Compared to Autologous Alveolar Macrophages in Response to the In Vivo Oxidant Stress of Cigarette Smoking The oxidant burden of cigarette smoking induces lung cell dysfunction, and play a significant role in the pathogenesis...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-13931 | biostudies-arrayexpress
TranscriptomicsSmoking-dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of COPD
Background: When exposed to specific stimuli, macrophages exhibit distinct activation programs, M1 and M2 polarization, that define macrophage function as inflammatory/immune effectors or anti-inflammatory/tissue remodeling cells, respectively. Due to their position on the lung epithelial surface, a...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-13896 | biostudies-arrayexpress
TranscriptomicsBiologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking
The first changes associated with smoking are in the small airway epithelium (SAE). Given that smoking alters SAE gene expression, but only a fraction of smokers develop chronic obstructive pulmonary disease (COPD), we hypothesized that assessment of SAE genome-wide gene expression would permit biol...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-11784 | biostudies-arrayexpress
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