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TranscriptomicsDifferential production of Type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages
Pattern recognition receptors (PRR) detect microbial products and induce cytokines which shape the immunological response. Interleukin-12 (IL-12), tumor necrosis factor alpha (TNF-α) and IL-1β are proinflammatory cytokines which can be essential for resistance against infection, but if produced at...
ORGANISM(S): Mus musculus 
2016-09-07 | E-GEOD-79809 | biostudies-arrayexpress
TranscriptomicsTrasncriptional response of human whole blood following TLR2 or TLR4 ligation in vitro
Use of human whole blood for transcriptomic analysis has potential advantages over the use of isolated immune cells for studying the transcriptional response to pathogens and their products. Whole blood stimulation can be carried out in a laboratory without the expertise or equipment to isolate immu...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-55375 | biostudies-arrayexpress
TranscriptomicsDetectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy
Analysis of UK blood transcriptional profiles before treatment to indentify changes that occur during (2 weeks, 2 months), at the end of treatment (6 months) and after treatment (12 months) Analysis of South African blood transcriptional profiles before treatment to indentify changes that occur duri...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-40553 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of blood, spleen and lung expression of C57BL/6 mice subjected to Burkholderia pseudomallei infection
Melioidosis, a severe human disease caused by the bacterium Burkholderia pseudomallei, has a wide spectrum of clinical manifestations ranging from acute septicaemia to chronic localized illness or latent infection. Mice were intranasally infected with either high or low doses of B. pseudomallei to g...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-61106 | biostudies-arrayexpress
GenomicsHomo sapiens
Trasncriptional response of human whole blood following TLR2 or TLR4 ligation in vitro
PRJNA239437 | ENA
TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 2]
Analysis of Mtb infected murine macrophages derived from C57Bl/6 WT, TPL2KO, IFNARKO & TPL2IFNAR DKO mice [Set 2] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune com...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47673 | biostudies-arrayexpress
TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 1]
Analysis of Mtb infected murine macrophages derived from C57Bl/6 WT, TPL2KO, IFNARKO & TPL2IFNAR DKO mice [Set 1] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune comp...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47672 | biostudies-arrayexpress
TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47674 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression profiles in individuals infected with the Human T-Lymphotropic virus Type 1 (HTLV-1) - test set
Infection with the human T lymphotropic virus type 1 (HTLV-1) remains asymptomatic in the majority of carriers; however, some 5% develop a chronic inflammation of the central nervous system termed HTLV-1-associated myelopathy (HAM). It is not well understood how the virus triggers the onset of HAM a...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-29332 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression profiles in individuals infected with the Human T-Lymphotropic virus Type 1 (HTLV-1) - train set
Infection with the human T lymphotropic virus type 1 (HTLV-1) remains asymptomatic in the majority of carriers; however, some 5% develop a chronic inflammation of the central nervous system termed HTLV-1-associated myelopathy (HAM). It is not well understood how the virus triggers the onset of HAM a...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-29312 | biostudies-arrayexpress
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