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TranscriptomicsDrosophila Oga deletion perturbs O-GlcNAcylation of chromatin factors
Drosophila development is a complex and dynamic process regulated, in part, by members of the Polycomb (Pc), Trithorax (Trx) and Compass chromatin modifier complexes. O-GlcNAc Transferase (OGT/SXC) is essential for Pc repression suggesting that the O-GlcNAcylation of proteins plays a key role in re...
ORGANISM(S): Drosophila melanogaster 
2016-07-21 | E-GEOD-74846 | biostudies-arrayexpress
ProteomicsO-GlcNAcase activity is necessary for the molecular signature of the Glioblastoma secretome
Glioblastoma (GBM) is a grade IV glioma highly aggressive and refractory to the therapeutic approaches currently in use nowadays. Although sugar metabolism through the hexosamine biosynthetic pathway (HBP) plays a key role in tumor aggressiveness and progression in different types of cancer, whether...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019496 | Pride
Glioblastoma secretome Lcms O-glcnacase activity 
ProteomicsSmall molecule-mediated O-GlcNAcase activation for precise control of O-GlcNAcylation in live cells
O-GlcNAc is a nutritionally and metabolically relevant post-translational modification on thousands of nucleocytoplas-mic proteins. O-GlcNAcylation level dynamically responds to environmental cues in temporal and spatial dimensions, leading to discrete signaling transductions and physiological effec...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD035686 | Pride
O-glcnacylation 
ProteomicsStress-induced interactome of the O-GlcNAcase by SILAC-BioID-MS/MS
O-linked-β-N-acetylglucosamine (O-GlcNAc) dynamically modifies and regulates thousands of nuclear, cytoplasmic, and mitochondrial proteins. Cellular stress, including oxidative stress, results in increased O-GlcNAcylation on numerous proteins and this is thought to promote cell survival. The mechani...
ORGANISM(S): Homo sapiens (Human) 
2017-03-14 | PXD005039 | Pride
Glycosylation Mgea5 Fasn Silac O-glcnac Human Bioid 
UnknownLoss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis.
Not available
S-EPMC7988489 | biostudies-literature
ProteomicsQuantitative Proteomics Reveals that the OGT Interactome is Remodeled in Response to Oxidative Stress
The dynamic modification of specific serine and threonine residues of intracellular proteins by O-linked N-acetyl-β-D-glucosamine (O-GlcNAc) mitigates injury and promotes cytoprotection in a variety of stress models. The O-GlcNAc transferase (OGT) and the O-GlcNAcase (OGA) are the sole enzymes that ...
ORGANISM(S): Mus Musculus 
2021-04-05 | PXD021091 | panorama
UnknownO-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.
Not available
S-EPMC7107572 | biostudies-literature
UnknownInsights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates.
Not available
S-EPMC3346082 | biostudies-literature
UnknownTarget protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase.
Not available
S-EPMC8085020 | biostudies-literature
UnknownFatty acid synthase inhibits the O-GlcNAcase during oxidative stress.
Not available
S-EPMC5399103 | biostudies-literature
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