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MetabolomicsMetabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway
Metabolic perturbations resulting from excessive hepatic fat accumulation are poorly understood. Thus, in this study, leptin-deficient ob/ob mice, a mouse model of fatty liver disease, were used to investigate metabolic alterations in more detail. Metabolites were quantified in intact liver tissues ...
2018-01-31 | MTBLS400 | MetaboLights
TranscriptomicsGene expression in the GWAT of ob/ob and ob/ob/Fsp27-/- mice
GWAT store most of the TAG in mice, ob/ob mice is an obese mice. Ob/ob/Fsp27-/- mice are lean when compared with ob/ob mice. The GWAT weight was dramatically reduced in ob/ob/Fsp27-/- mice. We next extract the total RNA from the GWAT of ob/ob and ob/ob/Fsp27-/- mice, to perform microaary analysis us...
ORGANISM(S): Mus musculus 
2015-04-17 | E-GEOD-59807 | biostudies-arrayexpress
MetabolomicsComprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart
The ectopic deposition of fat is thought to lead to lipotoxicity and has been associated with mitochondrial dysfunction and diabetic cardiomyopathy. We have measured mitochondrial respiratory capacities in the hearts of ob/ob and wild-type mice on either a regular chow (RCD) or high-fat (HFD) diet a...
2015-11-17 | MTBLS173 | MetaboLights
TranscriptomicsTranscription profiling of mouse ob/ob leptin-treated and ob/ob saline-treated lungs.
We hypothesize that gene expression in the lungs of these differentially-treated mice are divergent thus contributing to the disparity in their phenotypes. More specifically, (1) Effects of Leptin-treatment of ob/ob postnatal mice lungs are known to be volume-dependent from 2 to 10 wks of age, and a...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-10915 | biostudies-arrayexpress
GenomicsBurkholderia pseudomallei OB strain:OB
Burkholderia pseudomallei OB strain:OB Genome sequencing and assembly
PRJNA188495 | ENA
TranscriptomicsChanges in Hepatic Gene Expression upon Oral Administration of Taurine-Conjugated Ursodeoxycholic Acid in ob/ob Mice
We examined the effect of oral TUDCA treatment on hepatic steatosis and associated changes in hepatic gene expression in ob/ob mice. We administered TUDCA to ob/ob mice at a dose of 500 mg/kg twice a day by gastric gavage for 3 weeks. Body weight, glucose homeostasis, endoplasmic reticulum (ER) stre...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-22608 | biostudies-arrayexpress
ProteomicsLabel-free comparative data dependent (DDA) nanoLC-MS/MS analysis of redox mediated posttranslational modifications (PTMs) in the proteomes from mouse primary dendritic cells (DC) isolated from control B6 and obese (Ob/Ob) mice
Proteomic modifications linked to non-enzymatic glycation and glycoxidation are common in all tissues under hyperglycemic conditions, as present in metabolic syndrome, type 2 diabetes (T2D), mice bearing a homozygous mutation in leptin (so-called Ob/Ob mice, a common model of obesity and T2D) and mi...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD024239 | Pride
Control b6 and ob/ob mice dendritic cells Bottom-up proteomics on qehf and velos orbitrap 
TranscriptomicsGene expression in livers of Lepob/ob (ob/ob) mice v.s. wild type C57BL/6J mice
To identify novel transcriptional factors involved in dysfunctional hepatic lipids homeostasis in obesity, mRNA microarray analysis were performed to of livers of ob/ob mice, a widely used obese model, and C57BL/6J control mice. Chow-fed ob/ob and C57BL/6J mice were housed in a 12 h of light and 12...
ORGANISM(S): Mus musculus 
2014-06-29 | E-MTAB-2678 | biostudies-arrayexpress
ProteomicsProteomics of liver from ob/ob and WT mice
Proteomics of liver tissue from ob/ob and WT mice. Data accompany our paper entitled “Dynamic Regulation of N6,2′-O-dimethyladenosine (m6Am) in Obesity” scheduled for publication in Nature Communications, 2021
ORGANISM(S): Mus musculus (Mouse) 
2021-10-27 | PXD029217 | Pride
Mouse Liver Ob/ob 
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of ob/+ and ob/ob pancreatic islet Transcriptomes
Next Generation Sequencing Facilitates Quantitative Analysis of ob/+ and ob/ob pancreatic islet Transcriptomes
PRJNA655612 | ENA
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