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UnknownA second-generation genomewide screen for asthma-susceptibility alleles in a founder population.
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S-EPMC1288558 | biostudies-literature
TranscriptomicsGene expression data from peripheral blood leukocytes of Amish and Hutterite schoolchildren
The Amish and Hutterites are U.S. farming populations with remarkably similar lifestyles. However, the Amish follow traditional farming practices, while the Hutterites employ modern farming techniques, and also show striking differences in asthma prevalence. Little is known about immune responses un...
ORGANISM(S): Homo sapiens 
2016-08-05 | E-GEOD-85007 | biostudies-arrayexpress
TranscriptomicsThe Combination of a Genome-Wide Association Study of Lymphocyte Count and Analysis of Gene Expression Data Reveals Novel Asthma Candidate Genes
Recent genome-wide association studies (GWAS) have identified a number of novel genetic associations with complex human diseases. In spite of these successes, results from GWAS generally explain only a small proportion of disease heritability, an observation termed the M-bM-^@M-^\missing heritabilit...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-30697 | biostudies-arrayexpress
GenomicsGenetic Studies in the Hutterites

We conducted genome wide association studies (GWAS) of disease-associated quantitative phenotypes in the Hutterites, a founder population of European descent. The Hutterites in our studies live on communal farms in South Dakota and are related to each other through multiple lines of descent...

phs000185.v1.p1 | EGA
TranscriptomicsEndometrial expression profiling in women with recurrent early pregnancy loss
Pregnancy loss is the most common complication of human pregnancy. Recurrent early pregnancy loss (REPL) has multiple etiologies, including endometrial dysregulation leading to “suboptimal” implantation. Although the implantation process is tightly regulated in Eutherian (placental) mammals, the ...
ORGANISM(S): Homo sapiens 
2014-12-06 | E-GEOD-63901 | biostudies-arrayexpress
TranscriptomicsGene expression data from uninfected and rhinovirus-infected peripheral blood mononuclear cells from 98 individuals
Rhinovirus (RV) is the most prevalent human respiratory virus. Each year, RV infects billions of people and is responsible for at least half of all common colds, the most common illness of humans. RV infection also affects the morbidity of a range of respiratory illnesses, such as bronchiolitis, pne...
ORGANISM(S): Homo sapiens 
2015-04-14 | E-GEOD-53543 | biostudies-arrayexpress
TranscriptomicsThe effects of EBV transformation on gene expression
Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) provide a conveniently accessible and renewable resource for functional studies in humans. The ability to accumulate multidimensional data pertaining to the same individual cell lines, from complete genomic sequences to detailed g...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-26210 | biostudies-arrayexpress
TranscriptomicsThe effects of EBV transformation on methylation levels
Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) provide a conveniently accessible and renewable resource for functional studies in humans. The ability to accumulate multidimensional data pertaining to the same individual cell lines, from complete genomic sequences to detailed g...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-26211 | biostudies-arrayexpress
TranscriptomicsThe effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines
Epstein-Barr virus (EBV) transformed lymphoblastoid cell lines (LCLs) are a widely used renewable resource for functional genomic studies in humans. The ability to accumulate multidimensional data pertaining to the same individual cell lines, from complete genomic sequences to detailed gene regulato...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-58942 | biostudies-arrayexpress
TranscriptomicsExpression Quantitative Trait Locus Mapping Studies in Mid-Secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes
Fertility traits in humans are heritable, however, little is known about the genes that influence reproductive outcomes or the genetic variants that contribute to differences in these traits between individuals, particularly women. To address this gap in knowledge, we performed an unbiased genome-wi...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-77688 | biostudies-arrayexpress
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