Endometrial expression profiling in women with recurrent early pregnancy loss

ABSTRACT: Pregnancy loss is the most common complication of human pregnancy. Recurrent early pregnancy loss (REPL) has multiple etiologies, including endometrial dysregulation leading to “suboptimal” implantation. Although the implantation process is tightly regulated in Eutherian (placental) mammals, the molecular factors contributing to dysregulated endometrial gene expression patterns in women with REPL are largely unknown. We hypothesized that genes that gained novel expression in the endometria of mammals that evolved in the Eutherian stemlineage, coincident with the evolution of pregnancy, are likely essential for establishment and maintenance of normal pregnancy and are, therefore, good candidates for genes whose expression may be dysregulated in disorders such as REPL. To test this h

ORGANISM(S): Homo sapiens

SUBMITTER: Gulum Kosova 

PROVIDER: E-GEOD-63901 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress