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TranscriptomicsSIRT1 redistribution on chromatin promotes genome stability but alters gene expression during aging
This SuperSeries is composed of the following subset Series: GSE13075: SIRT1 and H1AcK26 promoter-association in mouse ES cells changes upon oxidative stress GSE13120: Age-related gene expression changes in mouse neocortex Refer to individual Series
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-13121 | biostudies-arrayexpress
TranscriptomicsSIRT1 and H1AcK26 promoter-association in mouse ES cells changes upon oxidative stress
Association of the (histone) deacetylase SIRT1 with promoters was assessed to determine putative SIRT1-regulated genes. Based on the observation that the SIRT1 yeast ortholog Sir2 redistributes across the yeast genome in repsonse to genotoxic stress and double strand breaks (DSBs), we investigated t...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-13075 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of I-PpoI induced DNA double strand breaks in mouse lymphocytes
DNA double-strand breaks (DSBs) and their repair can cause extensive epigenetic changes. As a result, DSBs have been proposed to promote transcriptional and, ultimately, physiological dysfunction via both cell-intrinsic and cell-non-autonomous pathways. Studying the consequences of DSBs in higher or...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-74855 | biostudies-arrayexpress
TranscriptomicsThree-dimensional proximity mapping of the DRGFP DNA double-strand break site in U2OS cells
We mapped the DNA sequences located in physical proximity to an I-SceI endonuclease-dependent DNA double-strand break (DSB) site to be able to study the impact of DSBs on the break-associated chromatin micro-environment. The I-SceI DSB site is part of a DRGFP transgene that serves as a reporter for ...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-58563 | biostudies-arrayexpress
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