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TranscriptomicsSmoking and Obesity Related Molecular Alterations in Clear Cell Renal Cell Carcinoma
Both cigarette smoking and obesity have been implicated in increased risk of clear cell renal cell carcinoma (ccRCC); however, there are limited data regarding the molecular mechanisms that underlie these associations. We used a multi-stage design to identify and validate specific molecular targe...
ORGANISM(S): Homo sapiens 
2014-01-10 | E-GEOD-46699 | biostudies-arrayexpress
TranscriptomicsEffect of perinatal obesity on premature kidney aging signaling
Chronic Kidney Disease (CKD), a global health burden, is strongly associated with age-related renal function decline, hypertension and diabetes, frequent consequences of obesity. Despite extensive studies the mechanisms determining susceptibility to CKD remain elusive. Clinical evidence together wit...
ORGANISM(S): Mus musculus 
2022-12-31 | E-MTAB-10954 | biostudies-arrayexpress
MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+injury analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4988 | MetaboLights
UnknownObesity and chronic kidney disease progression-the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1.
Not available
S-EPMC6543966 | biostudies-literature
UnknownATP-citrate lyase is an epigenetic regulator to promote obesity-related kidney injury.
Not available
S-EPMC6662982 | biostudies-literature
MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+diet analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4994 | MetaboLights
UnknownOptimal Obesity- and Lipid-Related Indices for Predicting Metabolic Syndrome in Chronic Kidney Disease Patients with and without Type 2 Diabetes Mellitus in China.
Not available
S-EPMC9002364 | biostudies-literature
UnknownACE2 deficiency exacerbates obesity-related glomerulopathy through its role in regulating lipid metabolism.
Not available
S-EPMC9523180 | biostudies-literature
ProteomicsA wide-proteome analysis to identify molecular pathways in-volved in kidney response to high fat diet in mice
The etiopathogenesis of obesity-related chronic kidney disease (CKD) is still scarcely understood. Aim of this study is to shed light on the molecular pathogenesis of obesity-induced CKD by assessing the effect of high fat diet (HF) on molecular pathways leading to organ damage, steatosis, and fibro...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD031915 | Pride
Proteomics  nanolc-ms/ms 
UnknownInflammatory stress promotes the development of obesity-related chronic kidney disease via CD36 in mice.
Not available
S-EPMC5496038 | biostudies-literature
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