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Proteomicsbinding specificity of Native Odorant-Binding Protein isoforms is driven by phosphorylation and O-N-acetylglucosamiylation in the pig (sus scrofa)
In pig, phosphorylation drives binding specificity of recombinant OBP (stricto sensu, referred as OBP in this text) isoforms (Brimau et al., 2010) that are not O-GlcNAcylated, contrary to native OBP, purified from nasal tissue (Nagnan-Le Meillour et al., 2014). In order to precise the role of both P...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2019-02-15 | PXD011371 | Pride
Cid-nano-lc-ms/ms Odorant-binding protein Fluorescence spectroscopy Pheromone O-glcnac Phosphorylation 
TranscriptomicsDevelopment of miRNA expression signatures for induction of histone deacetylase inhibitor (part 1)
To clarify the relationship between histone acetylation and miRNA expression, we performed miRNA arrays to detect histone deacetylase inhibitor (OBP-801) induced miRNA regulating AR expression in LNCaP and VCaP. Agilent-041686 Unrestricted Human miRNA Microarray (Agilent Technologies, Santa Clara, C...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-69487 | biostudies-arrayexpress
TranscriptomicsDevelopment of miRNA expression signatures for induction of histone deacetylase inhibitor (part 2)
To clarify the relationship between histone acetylation and miRNA expression, we performed miRNA arrays to detect histone deacetylase inhibitor (OBP-801) induced miRNA regulating AR expression in 22Rv1. Agilent-031181 Unrestricted Human miRNA Microarray (Agilent Technologies, Santa Clara, California...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-69488 | biostudies-arrayexpress
ProteomicsIdentification of post-translational modifications on Odorant-Binding Protein isoforms from pig olfactory secretome by high-resolution mass spectrometry: O-beta-N-acetylglucosaminylation and phosphorylation
Odorant-Binding Proteins (OBP) are players of perireceptor events in olfaction. A molecular mechanism explaining their specificity for odors and pheromones has still to be proposed. A new track comes from the analysis of pig olfactory secretome, which is mainly composed of OBP isoforms, generated fr...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-12-20 | PXD007955 | Pride
2-dimensional gel electrophoresis Odorant-binding protein O-glcnac Esi-hcd-ms/ms Phosphorylation 
GenomicsmiRNA expression data of rat prostate cancer tissue treated with OBP-801, novel HDAC inhibitor
miRNA expression was obtained from non-treated or OBP-801 treated TRAP rats which develop prostate cancer. The primary aim was to identify miRNAs which regulate prostate carcinogenesis induced by OBP-801.
ORGANISM(S): Rattus norvegicus 
2016-12-01 | GSE75020 | GEO
TranscriptomicsGene expression data of rat prostate cancer tissue treated with OBP-801, novel HDAC inhibitor
Genome-wide gene expression was obtained from non-treated or OBP-801 treated TRAP rats which develop prostate cancer. The primary aim was to identify genes which regulate prostate carcinogenesis induced by OBP-801.
ORGANISM(S): Rattus norvegicus 
2016-12-01 | GSE75021 | GEO
TranscriptomicsHTG EdgeSeq analysis of parental and CDK4/6i-resistant (Ribociclib or Palbociclib) T47D breast cancer cell clones
Do illuminate the vulnerabilities of CDK4/6i-resistant T47D breast cancer cells, we created CDK4/6i-resistant T47D cell clones through a gradual dose escalation protocol using the selective CDK4/6 inhibitors Ribociclib and Palbociclib. We then performed gene expression analysis targeting 2549 genes ...
ORGANISM(S): Homo sapiens 
2026-06-17 | E-MTAB-15265 | biostudies-arrayexpress
UnknownPluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model.
Not available
S-EPMC7708845 | biostudies-literature
TranscriptomicsTissue-specific transcriptomics, chromosomal localization, and phylogeny of chemosensory and odorant binding proteins from the red flour beetle Tribolium castaneum reveal subgroup specificities for olfaction or more general functions
Chemoreception is based on the senses of smell and taste that are crucial for animals to find new food sources, shelter, and mates. The initial step in olfaction involves the translocation of odorants from the periphery through the aqueous lymph of the olfactory sensilla to the odorant receptors by ...
ORGANISM(S): Tribolium castaneum 
2015-03-01 | E-GEOD-63162 | biostudies-arrayexpress
UnknownPluripotent epigenetic regulator OBP-801 attenuates fibrosis and maintains lower intraocular pressure in a rabbit PRESERFLO MicroShunt surgery model.
Not available
S-EPMC12858950 | biostudies-literature
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