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TranscriptomicsHuman Subperitoneal Fibroblasts and Cancer Cell Interaction Creates Microenvironment Enhancing Tumor Progression and Metastasis
Fibroblasts isolated from human colon submucosal and subperitoneal layer were stimulated by colon cancer cell line (DLD-1) cultured medium. Peritoneal invasion in colon cancer is an important prognostic factor, and the fibrosis with α-SMA was a significant pathological feature of the cancer microenv...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-53059 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of human colorectal cancer tissue
Generally, cancer tissue is palpated as a hard mass. On the other hand, it is not clear the nature of elasticity in cancer tissue. The aim in this study is to evaluate clinical utility of measuring elastic module in colorectal cancer tissue. Using a tactile sensor, we measured the elastic module of ...
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-65222 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of human fibroblasts from whole body
Fibroblasts are the principal stromal cells that exist in whole organs and play vital roles in many biological processes. Although the functional diversity of fibroblasts has been estimated, a comprehensive analysis of fibroblasts from the whole body has not been performed and their phenotypical div...
ORGANISM(S): Homo sapiens 
2014-11-26 | E-GEOD-63626 | biostudies-arrayexpress
TranscriptomicsLow SLC22A7 expression in noncancerous liver promotes hepatocellular carcinoma occurrence - a prospective study
Background & Aims: The recurrence determines the postoperative prognosis of patients with hepatocellular carcinoma (HCC). It is unknown whether de novo HCCs derive from the liver with disability of an organic anion transport. This study was designed to elucidate the link between such transporters an...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-40873 | biostudies-arrayexpress
TranscriptomicsMicroRNA markers for the diagnosis of pancreatic and biliary tract cancers
MicroRNAs from serum samples could detect pancreatic and biliary tract cancer patients more accurately than other traditional markers. Prospective miRNA markers for pancreatic/biliary tract cancer were selected in the training cohort. Using these miRNAs, discriminant analysis was performed, and the ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-59856 | biostudies-arrayexpress
TranscriptomicsThe transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program
Mature lymphoid cells express the transcriptional repressor Bach2, which imposes regulation on humoral and cellular immunity. Here we found critical roles for Bach2 in the development of cells of the B lineage, commencing from the common lymphoid progenitor (CLP) stage, with Bach1 as an auxiliary. O...
ORGANISM(S): Mus musculus 
2014-10-26 | E-GEOD-61409 | biostudies-arrayexpress
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