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ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam16 SILAC RNAi
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD046840 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Silac Maxicircle replication Rnai-mediated protein knockdown 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam18 SILAC RNAiTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam18 SILAC RNAi
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD046845 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Silac Maxicircle replication Rnai-mediated protein knockdown 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – MaRF11 SILAC RNAi
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD053251 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Silac Maxicircle replication Rnai-mediated protein knockdown 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam16 CoIPs
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD046849 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Affinity purification-mass spectrometry Silac Maxicircle replication 
ProteomicsA trypanosome-specific complex mediates late-stage processing of cytosolic LSU rRNA
Unlike most eukaryotes, Trypanosoma brucei processes its cytosolic large subunit (LSU) RNA into six fragments. The factors responsible for these processing events were previously unknown. Here, we identify TbLrRP1 and TbLrRP2 as essential components of this trypanosome-specific LSU RNA processing pa...
ORGANISM(S): Trypanosoma brucei 
2025-10-23 | PXD066890 | Pride
Trypanosoma brucei Proteomics Rrna processing Affinity purification-mass spectrometry Silac 
ProteomicsAn Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of trypanosomes (SILAC-IP data)
The AAA-ATPase Msp1 extracts mislocalized outer membrane proteins and thus contributes to mitochondrial proteostasis. Using pull down experiments, we show that trypanosomal Msp1 localizes to both the glycosome and the mitochondrial outer membrane, where it forms a stable complex with four outer memb...
ORGANISM(S): Trypanosoma brucei 
2023-07-26 | PXD039631 | Pride
Trypanosoma brucei Proteomics Co-immunoprecipitation Silac Mitochondrial quality control 
ProteomicsThe yeast peroxisomal proteome at absolute quantitative scale
Peroxisomes are dynamic organelles vital for lipid metabolism and redox homeostasis. In Saccharomyces cerevisiae, the expression of peroxisomal proteins is tightly regulated in response to metabolic conditions. Here, we provide the first absolute quantification of the yeast peroxisomal proteome unde...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-02-16 | PXD069526 | Pride
Saccharomyces cerevisiae  peroxisomes  protein copy numbers  absolute quantification  proteomic ruler  mass spectrometry 
ProteomicsSilencing mitochondrial gene expression in living cells – CYTB- and ND2-KD data
Mitochondria fullfill central functions in cellular metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms underlying mitochondrial gene expression remain enigmatic. A lack of suitable technologies ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD061846 | Pride
Oxidative phosphorylation Mitochondria Mitochondrial ribosome Quantitative mass spectrometry Hek293t cells Gene expression Label-free Translation 
ProteomicsSilencing mitochondrial gene expression in living cells – FLAG IPs
Mitochondria fullfill central functions in cellular metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms underlying mitochondrial gene expression remain enigmatic. A lack of suitable technologies ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD061877 | Pride
Oxidative phosphorylation Mitochondria Mitochondrial ribosome Hek293t cells Gene expression Quantitative ap-ms Label-free Translation 
ProteomicsSilencing mitochondrial gene expression in living cells – COX1-KD data
Mitochondria fullfill central functions in cellular metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms underlying mitochondrial gene expression remain enigmatic. A lack of suitable technologies ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD061876 | Pride
Oxidative phosphorylation Mitochondria Mitochondrial ribosome Quantitative mass spectrometry Hek293t cells Gene expression Label-free Translation 
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