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GenomicsOGT knockout S2VP10 cells
OGT knockout S2VP10 cells
PRJNA471509 | ENA
GenomicsTET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
TET proteins convert 5-methylcytosine to 5-hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has linked TET1 function to epigenetic repression complexes, yet mechanistic information, especially for the TET2 and TET3 proteins, remains limite...
ORGANISM(S): Mus musculus 
2013-02-07 | E-GEOD-36620 | biostudies-arrayexpress
ProteomicsDeficiency of OGT-mediated O-GlcNAcylation causes female infertility with oocyte meiotic arrest and follicle development defects by impairing mitochondrial function
Abnormalities in oocyte meiosis are a major cause of female infertility. Since transcriptional activity is largely absent during oocyte meiosis, post-translational modifications of proteins play an essential regulatory role. Among these, OGT-mediated O-GlcNAcylation is a key modification involved in...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-31 | PXD071809 | Pride
Ogt  o-glcnacylation  female infertility  oocyte  mitochondrial function 
ProteomicsDeficiency of OGT-mediated O-GlcNAcylation causes female infertility with oocyte meiotic arrest and follicle development defects by impairing mitochondrial function
Abnormalities in oocyte meiosis are a major cause of female infertility. Since transcriptional activity is largely absent during oocyte meiosis, post-translational modifications of proteins play an essential regulatory role. Among these, OGT-mediated O-GlcNAcylation is a key modification involved in...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-31 | PXD071865 | Pride
Ogt  o-glcnacylation  female infertility  oocyte  mitochondrial function 
TranscriptomicsOGT knockout S2VP10 cells
Pancreatic Cancer cells were transfected with CRISR based OGT knockouts
ORGANISM(S): Homo sapiens 
2019-06-01 | GSE114472 | GEO
GenomicsOGT suppresses macrophage proinflammatory activation
OGT suppresses macrophage proinflammatory activation
PRJNA607991 | ENA
GenomicsGenome-wide changes in OGT-deficient mouse liver tissue
Genome-wide changes in OGT-deficient mouse liver tissue
PRJNA557230 | ENA
GenomicsGenome-wide changes in OGT-depleted mouse adipose tissue
Genome-wide changes in OGT-depleted mouse adipose tissue
PRJNA437991 | ENA
GenomicsEffect of depletion of OGT on gene expression during M2 polarization of macrophages
Effect of depletion of OGT on gene expression during M2 polarization of macrophages
PRJNA864616 | ENA
TranscriptomicsEffect of depletion of OGT on gene expression during M2 polarization of macrophages
To investigate the function OGT in the regulation of M2 polarization of macrophages, we established IL-4-activated bone marrow-derived macrophages (BMDMs) from mice of wild-type control or Lyz2-Cre/Loxp-mediated knockout of OGT. We then performed gene expression profiling analysis using data obtaine...
ORGANISM(S): Mus musculus 
2022-09-08 | GSE210176 | GEO
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