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Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...
ORGANISM(S): Homo sapiens 
Hemocytes were sorted from stage 16 embryos and wandering 3rd instar larvae in which gcm was knocked down using gcmRNAi and the driver srp(hemo)Gal4. The experiments were done in triplicate. The wild type controls at stage 16 embryo and wandering larvae are available under this assession number: E-M...
ORGANISM(S): Drosophila melanogaster 
Title: Changes in gene expression affected by H2O2 in cardiac myocytes.
Description: We aim to identify the changes in gene expression in response to
oxidative stress in rat neonatal ventricular myocytes.
Oxidative stress will be induced by dosing neonatal ventricular myocyte...
ORGANISM(S): Rattus norvegicus 
We are determining the effects of oxidative stress on mRNA expression in cardiac myocytes to identify immediate early genes and establish if there is an effect of different concentrations on recruitment to polysomes for translation. Rat neonatal cardiac myocytes in primary culture were exposed to 0...
ORGANISM(S): Rattus norvegicus 
Cardiomyocytes, the terminally-differentiated contractile cells of the heart, undergo hypertrophic growth in response to endothelin-1. This is associated with changes in mRNA expression of immediate early genes (IEGs). Atf3 is a member of the ATF/CREB family transcription factors which bind as dim...
ORGANISM(S): Rattus norvegicus 
Copper is an essential component of cytochrome C oxidase (i.e. complex IV of the electron transport chain), and is thus critical for the survival of aerobic organisms. If copper is not properly regulated in the body however, it can be extremely cytotoxic and genetic mutations that compromise copper ...
ORGANISM(S): Saccharomyces cerevisiae 
The aim of this experiment is to compare the transcriptome of Drosophila hemocytes at two developmental stages: in stage 16 embryo, mostly free from any immune challenge and in larvae, which grow in bacteria rich environment. Transgenes inducing the expression of RFP in the hemocytes were used to so...
ORGANISM(S): Drosophila melanogaster 
Title: Regulation of gene expression through mitogen-activated protein kinase cascades in cardiac myocytes.
Description: We aim to identify the changes in gene expression induced in rat
neonatal ventricular myocytes, a well established cell culture model,
by phenylepherine, ...
ORGANISM(S): Rattus norvegicus 
The Squalius alburnoides complex (Steindachner) is one of the most intricate hybrid polyploid systems known in vertebrates. In this complex, the constant switch of the genome composition in consecutive generations, very frequently involving a change on the ploidy level, promotes repetitive situation...
ORGANISM(S): Squalius pyrenaicus 
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