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TranscriptomicsMultiple insert size paired-end sequencing for deconvolution of complex transcriptomes
Deep sequencing of transcriptomes allows quantitative and qualitative analysis of many RNA species in a sample, with parallel comparison of expression levels, splicing variants, natural antisense transcripts, RNA editing and transcriptional start and stop sites the ideal goal. By computational model...
ORGANISM(S): Caenorhabditis elegans 
2012-08-31 | E-GEOD-40507 | biostudies-arrayexpress
UnknownOrganophosphorus S-adenosyl-L-methionine mimetics: synthesis, stability, and substrate properties.
Not available
S-EPMC11325224 | biostudies-literature
TranscriptomicsTowards an understanding of the mechanism of action of praziquantel
Although praziquantel (PZQ) has been used to treat schistosomiasis for over 20 years its mechanism of action remains unknown. We have developed an assay based on the transcriptional response of S. mansoni PR-1 to heat shock to confirm that while 6 week post infection (p.i.) schistosomes are sensitiv...
ORGANISM(S): Schistosoma mansoni 
2008-11-10 | E-GEOD-12850 | biostudies-arrayexpress
TranscriptomicsFunction of Periplasmic Hydrogenases in the Sulfate-Reducing Bacterium Desulfovibrio vulgaris Hildenborough
The sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough possesses four periplasmic hydrogenases to facilitate the oxidation of molecular hydrogen. These include an [Fe], a [NiFeSe] and two [NiFe] hydrogenases encoded by the hyd, hys, hyn1 and hyn2 genes, respectively. In order to underst...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2010-06-10 | E-GEOD-8137 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression in the maize shoot apical meristem
All above ground organs of higher plants are ultimately derived from specialized organogenic structures called shoot apical meristems (SAMs). It is comprised of pluripotent stem cells, which divide to regenerate themselves as well as to provide cells to form other organs such as leaves and stems. To...
ORGANISM(S): Zea mays 
2010-06-25 | E-GEOD-4004 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae (budding yeast) mutants reveals Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and programmed cell death
Changes in the transcriptome of Isc1p deficient mutants. The inositolphosphosphingolipid phospholipase C (Isc1p) of Saccharomyces cerevisiae belongs to the family of neutral sphingomyelinases that generates the bioactive sphingolipid ceramide. In this work the role of Isc1p in oxidative stress resis...
ORGANISM(S): Saccharomyces cerevisiae 
2008-02-05 | E-MEXP-1136 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis in the shoot apical meristem of maize
All above ground organs of higher plants are ultimately derived from specialized organogenic structures called shoot apical meristems (SAMs). It is comprised of pluripotent stem cells, which divide to regenerate themselves as well as to provide cells to form other organs such as leaves and stems. To...
ORGANISM(S): Zea mays 
2010-06-25 | E-GEOD-4722 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the Streptococcus suis serotype 2 transcriptional response to acidic conditions
For a pathogen such as Streptococcus suis serotype 2, ecological success is determined by its ability to sense the environment and mount an appropriate adaptive transcriptional response. Thus, determining conditions for analysis of gene expression in vitro that are representative of the in vivo envi...
ORGANISM(S): Streptococcus suis 05ZYH33 
2011-09-12 | E-GEOD-21295 | biostudies-arrayexpress
TranscriptomicsTea tree oil induced transcriptional alterations in Staphylococcus aureus
S. aureus and MRSA are susceptible to TTO and are therefore targeted in nascent TTO clinical trails. We now report the alterations in the transcriptome of a S. aureus exposed to a growth inhibitory concentration of TTO. These efforts have uncovered additional mechanisms by which this membrane active...
ORGANISM(S): Staphylococcus aureus 
2012-04-25 | E-GEOD-31554 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast recovery after hydrogen peroxide stress
Yeast cells response during recovery after hydrogen peroxide stress. Comparison of yeast cells treated with 1.5mM hydrogen peroxide for 30 min with cells allowed to recover for 60 min
ORGANISM(S): Saccharomyces cerevisiae 
2006-01-28 | E-MEXP-326 | biostudies-arrayexpress
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