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TranscriptomicsTranscription profiling of human U927 cells polysomal and cytoplasmic RNA before and after PMA stimulation
Human histomonocytic U937 cells exhibit macrophage-like properties after phorbol ester stimulation. Accumulating evidence demonstrated that remarkable number of transcripts changed in their amount at total RNA levels. However, post-transcriptional regulation has not been fully elucidated in this m...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1783 | biostudies-arrayexpress
TranscriptomicsNickel Chloride (NiCl2) effect on human T cells from whole blood
Analysis of anti-CD3/anti-CD28 stimulated T cells treated with or without nickel chloride. Nickel is the most important contact allergen in the general population of the industrialized world. Results provide insight into the biological effects of nickel on human CD3+ T cells. We obtained mRNA of pur...
ORGANISM(S): Homo sapiens 
2011-05-18 | E-GEOD-23387 | biostudies-arrayexpress
TranscriptomicsComparision of expression profile between wild-type and Slc39a13 knockout osteoblasts
In order to explore molecules whose expression is controlled by Slc39a13, we investigated gene expression profiling of primary osteoblast isolated from wild-type and Slc39a13 knockout mice. Keywords: knockout vs wild-type wild-type vs Slc39a13 knockout
ORGANISM(S): Mus musculus 
2008-11-07 | E-GEOD-10555 | biostudies-arrayexpress
TranscriptomicsEffects of PMA on exon usage of HL60, THP-1, and U937 cells
Myeloid leukemia cell lines HL60, THP-1, and U937 undergo macrophage-like differentiation after treatment with phorbol ester. To explore genes whose exon usage was altered during macrophage differentiation, we compared exome of PMA-treated (differentated) and vehicle-treated (undifferentiated) myelo...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-20567 | biostudies-arrayexpress
TranscriptomicsEffects of gene scilencing of USP2 on expression profiles of HL60 cells
So far, we have found PMA induced USP2b isoform in myeloid leukemia cell lines such as HL60, THP-1, and U937. To explore molecular function of USP2 in the cells, we assess expression profiles of HL60-derivatives continuously expressing shRNA for USP2 and control shRNA. HL60 derivatives continuously ...
ORGANISM(S): Homo sapiens 
2013-08-27 | E-GEOD-20476 | biostudies-arrayexpress
TranscriptomicsInterleukin-4 and interleukin-13 cytokines effect on epidermal keratinocytes
Analysis of cultured epidermal keratinocytes treated with interleukin-4 (IL-4) and interleukin-13 (IL-13). IL-4 and IL-13 are up-regulated in atopic dermatitis. Results provide insight into the role of IL-4 and IL-13 cytokines in the pathogenesis of atopic dermatitis. Analysis of epidermal keratino...
ORGANISM(S): Homo sapiens 
2010-10-31 | E-GEOD-20706 | biostudies-arrayexpress
TranscriptomicsGene expression of the colonic epithelial cells in CRB mice fed with HFD and LFD
To elucidate the mechamisms of colonic Treg cell induction by microbial metabolite(s), chroloform-resistant bacteria (CRB)-associated mice was developed and given low-fiber diet (LFD) and high-fiber diet (HFD). The colonic epithelial cells were isolated and gene expression profiles were analyzed by ...
ORGANISM(S): Mus musculus 
2014-08-11 | E-GEOD-41104 | biostudies-arrayexpress
ProteomicsDemonstration of a complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis
Genetic diagnosis plays a central role in the clinical management of patients with inborn errors of immunity (IEI). We proposed a novel method for diagnosing IEI using PBMC proteomics integrated with targeted RNA sequencing, providing notable insights into the pathogenesis of IEI. Data-independent a...
ORGANISM(S): Homo Sapiens (human) 
2023-11-25 | PXD038352 | JPOST Repository
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