Sort   by:  
 Page size 
GenomicsAP-1 family members act at DNA targets in conjunction with Sox9 to promote chondrocyte hypertrophy
A comprehensive analysis of Sox9 binding profiles in developing chondrocytes identified marked enrichment of an AP-1-like motif (Ohba et al. 2015). Here, we have explored the functional interplay between Sox9 and AP-1 in mammalian chondrocyte development. Among AP-1 family members, Jun and Fosl2 wer...
ORGANISM(S): Mus musculus 
2016-02-29 | E-GEOD-73372 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to Wnt pathway stimulation in mouse embryonic stem cells cultured in serum+LIF condition
The objective of this study was to identify genes regulated by canonical Wnt signaling in mouse embryonic stem cells (ESCs).Canonical Wnt signaling supports the pluripotency of mouse ESCs but also promotes differentiation of early mammalian cell lineages. To explain these paradoxical observations, ...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-43420 | biostudies-arrayexpress
GenomicsChIP-seq analysis of M-NM-2-catenin in mouse embryonic stem cells treated with GSK3 inhibitor CHIR99021 under serum+LIF standard condition.
The objective of this study was to identify the direct target genes of M-NM-2-catenin acting downstream of canonical Wnt signaling in mouse embryonic stem cells (ESCs).Canonical Wnt signaling supports the pluripotency of mouse ESCs but also promotes differentiation of early mammalian cell lineages. ...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-43565 | biostudies-arrayexpress
TranscriptomicsDistinct regulatory programs for Sox9 in transcriptional regulation of the developing mammalian chondrocyte [expression array]
We compared Sox9-association at chondrocyte targets to a broad catalogue of regulatory indicators of chromatin organization and transcriptional activity to determine Sox9’s direct regulatory actions in normal developing chondrocytes. Sox9-associated regions resolve into two distinct regulatory categ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-69108 | biostudies-arrayexpress
TranscriptomicsDistinct regulatory programs for Sox9 in transcriptional regulation of the developing mammalian chondrocyte [RNA-seq]
We compared Sox9-association at chondrocyte targets to a broad catalogue of regulatory indicators of chromatin organization and transcriptional activity to determine Sox9’s direct regulatory actions in normal developing chondrocytes. Sox9-associated regions resolve into two distinct regulatory categ...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-69110 | biostudies-arrayexpress
GenomicsDistinct regulatory programs for Sox9 in transcriptional regulation of the developing mammalian chondrocyte [ChIP-seq]
We compared Sox9-association at chondrocyte targets to a broad catalogue of regulatory indicators of chromatin organization and transcriptional activity to determine Sox9’s direct regulatory actions in normal developing chondrocytes. Sox9-associated regions resolve into two distinct regulatory categ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-69109 | biostudies-arrayexpress
Sort   by:  
 Page size