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TranscriptomicsTranscription profiling of human NK-cell associated receptors expression in EBV-positive gamma-delta T cell lines.
The contribution of chronic antigen stimulation to the occurrence of lymphoproliferative disorder (LPD) with the gamma-delta T-cell lineage is unclear, despite the fact that Epstein-Barr virus (EBV) positive T-cell LPD is derived from antigen-stimulated cytotoxic T-cells. Given the possible associat...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-13906 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult T cell leukemia cell lines to investigate the biological pathways of Hsp90 inhibitors
Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma (Mitsiades e...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-12287 | biostudies-arrayexpress
UnknownExosomal miRNA Signatures for Late-Onset Acute Graft-Versus-Host Disease in Allogenic Hematopoietic Stem Cell Transplantation.
Not available
S-EPMC6164670 | biostudies-literature
UnknownDownregulation of Plasma miR-215 in Chronic Myeloid Leukemia Patients with Successful Discontinuation of Imatinib.
Not available
S-EPMC4849026 | biostudies-literature
TranscriptomicsTranscription profiling of four human Adult T-cell leukemia (ATL) cell lines treated with proteasome inhibitor, bortezomib
Adult T-cell leukemia (ATL) is a fatal neoplasia derived from HTLV-1 infected T lymphocytes exhibiting constitutive activation of NF-kB. To elucidate the complex molecular mechanism of anti-tumor effect of the proteasome inhibitor, bortezomib in ATL cells, we attempted to perform gene expression pr...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6034 | biostudies-arrayexpress
TranscriptomicsBioligical pathways and in vitro anti-proliferative activity of Hsp90 inhibition in adult T cell leukemia cells
Background. Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma...
ORGANISM(S): Homo sapiens 
2009-05-27 | E-GEOD-12257 | biostudies-arrayexpress
TranscriptomicsDown-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients
MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor suppressor functions. Despite th...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-14772 | biostudies-arrayexpress
TranscriptomicsDynamics of intercellular and extracellular (exosomal) miRNAs in hypoxic K562 cells
Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. To gain more insight into cell-cell communication via exosomal miRNAs, we investigated whether or not tumor cells exposed to hypoxia secrete ex...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45289 | biostudies-arrayexpress
UnknownAge-related decrease of miRNA-92a levels in human CD8+ T-cells correlates with a reduction of naive T lymphocytes.
Not available
S-EPMC3225295 | biostudies-literature
UnknownDownregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders.
Not available
S-EPMC3270255 | biostudies-literature
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