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TranscriptomicsTranscription profiling of human hypothalamic hamartomas (HH) obtained from patients with or without precocious puberty (CPP)
Hypothalamic hamartomas (HHs) are congenital lesions of the neuroendocrine brain composed of neurons and astroglia. Frequently, HHs are associated with central precocious puberty (CPP) and/or gelastic seizures. Because HHs might express genes similar to those required for the initiation of normal pu...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7142 | biostudies-arrayexpress
TranscriptomicsPromoter methylation analysis in rat Pubertal Hypothalamus
Promoter methylation analysis of hypothalamc DNA from female rats at different juvenile developmental reproductive stages. Results provide insight into the role of the hypothalamus in controlling the onset of puberty. SD rats were housed (4/cage) in a controlled environment and euthanized at differe...
ORGANISM(S): Rattus norvegicus 
2012-06-05 | E-GEOD-38505 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human super frontal gyrus (post mortem brain) from Rett syndrome patients and age sex matched controls reveals FXYD1, an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice
Rett syndrome (RTT, OMIM 312750) is a severe X-linked neurodevelopmental disorder linked to heterozygous de novo mutations in the MECP2 gene. MECP2 encodes methyl-CpG-binding protein 2 (MeCP2), which represses gene transcription by binding to 5-methylcytosine residues in symmetrically positioned CpG...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-6955 | biostudies-arrayexpress
TranscriptomicsMolecular and Structural Bases of Hypothalamic Development
To compare the global profile of hypothalamic gene expression in agonadal male infants before and after activation of the neurobiologic brake that arrests pulsatile GnRH release during the juvenile phase of development. Affymetrix arrays were used to detect global changes in gene expression in the h...
ORGANISM(S): Macaca mulatta 
2014-12-19 | E-GEOD-64347 | biostudies-arrayexpress
TranscriptomicsMolecular and Structural Bases of Hypothalamic Puberty
To compare the global profile of hypothalamic gene expression in agonadal male Rhesus Monkeys before and after reactivation of the pulsatile GnRH release during the pubertal phase of development. 20 Samples looking at Cortex and Mediobasal hypothalamus in 3 stages of Rhesus Monkeys (early pubertal, ...
ORGANISM(S): Macaca mulatta 
2014-12-20 | E-GEOD-64396 | biostudies-arrayexpress
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