Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of human hypothalamic hamartomas (HH) obtained from patients with or without precocious puberty (CPP)

ABSTRACT: Hypothalamic hamartomas (HHs) are congenital lesions of the neuroendocrine brain composed of neurons and astroglia. Frequently, HHs are associated with central precocious puberty (CPP) and/or gelastic seizures. Because HHs might express genes similar to those required for the initiation of normal puberty we used cDNA arrays to compare the gene expression profile of a HH associated with CPP with three HHs not accompanied by sexual precocity. Our aim was to identify genes whose expression may be selectively altered in the HH with CPP and hence, involved in the onset of puberty. Experiment Overall Design: Affymetrix arrays were used to detect global changes in gene expression. The results of this analysis were confirmed by semi-quantitative PCR.

ORGANISM(S): Homo sapiens

SUBMITTER: valerie matagne

PROVIDER: E-GEOD-7142 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profiling of hypothalamic hamartomas: a search for genes associated with central precocious puberty.

Parent Anne-Simone AS Matagne Valerie V Westphal Manfred M Heger Sabine S Ojeda Sergio S Jung Heike H

Hormone research 20071205 2

<h4>Background</h4>Hypothalamic hamartomas (HHs) are congenital lesions composed of neurons and astroglia. Frequently, HHs cause central precocious puberty (CPP) and/or gelastic seizures. Because HHs might express genes similar to those required for the initiation of normal puberty, we used cDNA arrays to compare the gene expression profile of an HH associated with CPP with three HHs not accompanied by sexual precocity.<h4>Methods</h4>Global changes in gene expression were detected using Affymet ...[more]

PMID: 18059092

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Dataset Information

Transcription profiling of human hypothalamic hamartomas (HH) obtained from patients with or without precocious puberty (CPP)

Publications

Gene expression profiling of hypothalamic hamartomas: a search for genes associated with central precocious puberty.

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