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TranscriptomicsPARVB overexpression increases migration capability and defines high risks for endophytic growth and metastasis in tongue squamous cell carcinoma.
Tongue squamous cell carcinoma (TSCC) varies in characteristics even in early stages and is mainly classified into three subtypes, which are superficial, exophytic and endophytic types, based on a macroscopic appearance of tumor growth.Of these subtypes, endophytic tumor has a poorer prognosis becau...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-52915 | biostudies-arrayexpress
TranscriptomicsGene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and oligonucleotide microarray analysis
Background. Oral carcinogenesis is a complex process involving multiple genes. However, the genetic changes involved in this process are not demonstrated in the identical oral squamous carcinomas (OSCCs). Methods. According to the pathological characteristics, parts of normal tissues, oral dysplasti...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-35261 | biostudies-arrayexpress
TranscriptomicsExpression profiling in primary embryonic fibroblasts deficient for the N-terminal truncation of Lats1
Lats1 and Lats2 are the mediators of the Hippo pathway that regulates tissue growth and proliferation. Lats1 and Lats2 kinases share 85% sequence identity in the kinase domain. However, their non-kinase regions at the N-terminus are distinct except for Lats conserved domain 1 (LCD1) and LCD2, sugges...
ORGANISM(S): Mus musculus 
2012-12-17 | E-GEOD-37871 | biostudies-arrayexpress
UnknownAutomated Quantification of Extranuclear ERα using Phosphor-integrated Dots for Predicting Endocrine Therapy Resistance in HR+/HER2- Breast Cancer.
Not available
S-EPMC6520781 | biostudies-literature
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
ProteomicsPlasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in spaceflight-induced deterioration of muscul...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-01 | PXD041806 | JPOST Repository
TranscriptomicsGene expression profile of duodenal follicular lymphoma
To clarify the molecular pathogenesis of DFL pathogenesis using GEP. DFL shares characteristics of both NFL and MALT lymphoma. 55 total samples were examined; 10 DFL, 18 NFL, 10 gastric MALT lymphoma, 5 normal duodenal mucosa, 8 nodal reactive lymphoid hyperplasia, and 4 normal gastric mucosa.
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-48047 | biostudies-arrayexpress
ProteomicsGene expression profile of epithelial cells from five regions of human intestinal.
Data independent analysis of proteome of patient derived epithelial cell from five regions, duodenum, jejunum, ileum, colon and rectum.
ORGANISM(S): Homo Sapiens (human) 
2023-05-08 | PXD037197 | JPOST Repository
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