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TranscriptomicsNext-generation sequencing of Okazaki fragments extracted from Saccharomyces cerevisiae
We investigated the genome-wide distribution of Okazaki fragments in the commonly used laboratory Saccharomyces cerevisiae strain S288C to study the DNA replication model adopted by the budding yeast. The method based upon lambda exonuclease digestion for purification of RNA-primed replication inter...
ORGANISM(S): Saccharomyces cerevisiae 
2013-06-18 | E-GEOD-42929 | biostudies-arrayexpress
OtherNext-generation sequencing of Okazaki fragments extracted from Saccharomyces cerevisiae
We investigated the genome-wide distribution of Okazaki fragments in the commonly used laboratory Saccharomyces cerevisiae strain S288C to study the DNA replication model adopted by the budding yeast. The method based upon lambda exonuclease digestion for purification of RNA-primed replication inter...
ORGANISM(S): Saccharomyces cerevisiae 
2013-06-18 | GSE42929 | GEO
UnknownThe Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication.
Not available
S-EPMC6060609 | biostudies-literature
UnknownDePARylation is critical for S phase progression and cell survival.
Not available
S-EPMC10418084 | biostudies-literature
UnknownDePARylation is critical for S phase progression and cell survival.
Not available
S-EPMC10997334 | biostudies-literature
OtherProcessing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo
Prior to ligation, each Okazaki fragment synthesized on the lagging strand in eukaryotes must be nucleolytically processed. Nuclease cleavage takes place in the context of 5’ flap structures generated via strand-displacement synthesis by DNA polymerase delta. At least three DNA nucleases: Rad27 (Fen...
ORGANISM(S): Saccharomyces cerevisiae 
2018-08-04 | GSE118078 | GEO
UnknownComparison of the genome structure of the self-incompatibility (S) locus in interspecific pairs of S haplotypes.
Not available
S-EPMC1526501 | biostudies-literature
ProteomicsPARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed
Poly(ADP-ribose) polymerase (PARP) inhibitors have proven their efficacy for treating tumors defective in homologous recombination via synthetic lethality. In response to DNA breaks, PARP1 is the primary ADP-ribosylation writer, modifying itself (auto-modification) and other proteins to facilitate r...
ORGANISM(S): Homo sapiens (Human) 
2025-10-02 | PXD066033 | Pride
Parp1 Ptm Okazaki fragment Adp-ribosylation Dna replication 
GenomicsProcessing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo
Processing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo
PRJNA484362 | ENA
ProteomicsPARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed
Poly(ADP-ribose) polymerase (PARP) inhibitors have proven their efficacy for treating tumors defective in homologous recombination via synthetic lethality. In response to DNA breaks, PARP1 is the primary ADP-ribosylation writer, modifying itself (auto-modification) and other proteins to facilitate r...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2025-10-02 | PXD052191 | Pride
Okazaki fragment processing Parp1 Dna repair Af1521 macrodomain Adp-ribosylation Xenopus egg extract Auto-modification Dna replication 
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