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ProteomicsPARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed
Poly(ADP-ribose) polymerase (PARP) inhibitors have proven their efficacy for treating tumors defective in homologous recombination via synthetic lethality. In response to DNA breaks, PARP1 is the primary ADP-ribosylation writer, modifying itself (auto-modification) and other proteins to facilitate r...
ORGANISM(S): Homo sapiens (Human) 
2025-10-02 | PXD066033 | Pride
Parp1 Ptm Okazaki fragment Adp-ribosylation Dna replication 
ProteomicsPARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed
Poly(ADP-ribose) polymerase (PARP) inhibitors have proven their efficacy for treating tumors defective in homologous recombination via synthetic lethality. In response to DNA breaks, PARP1 is the primary ADP-ribosylation writer, modifying itself (auto-modification) and other proteins to facilitate r...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2025-10-02 | PXD052191 | Pride
Okazaki fragment processing Parp1 Dna repair Af1521 macrodomain Adp-ribosylation Xenopus egg extract Auto-modification Dna replication 
UnknownDynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation.
Not available
S-EPMC8727043 | biostudies-literature
UnknownDynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.
Not available
S-EPMC3825817 | biostudies-literature
UnknownThe trans-autostimulatory activity of Rad27 suppresses dna2 defects in Okazaki fragment processing.
Not available
S-EPMC3308799 | biostudies-literature
UnknownAn alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase.
Not available
S-EPMC3009898 | biostudies-literature
GenomicsProcessing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo
Processing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo
PRJNA484362 | ENA
OtherProcessing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo
Prior to ligation, each Okazaki fragment synthesized on the lagging strand in eukaryotes must be nucleolytically processed. Nuclease cleavage takes place in the context of 5’ flap structures generated via strand-displacement synthesis by DNA polymerase delta. At least three DNA nucleases: Rad27 (Fen...
ORGANISM(S): Saccharomyces cerevisiae 
2018-08-04 | GSE118078 | GEO
UnknownGenetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.
Not available
S-EPMC4636136 | biostudies-literature
UnknownMsh2-Msh3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions.
Not available
S-EPMC3459598 | biostudies-literature
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