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UnknownBDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.

Objective

To examine the influence of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on longitudinal cognitive trajectories in a large, cognitively healthy cohort enriched for Alzheimer disease (AD) risk and to understand whether β-amyloid (Aβ) burden plays a moder...
S-EPMC5447398 | biostudies-literature
UnknownKLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD.

Objective

To examine whether the KLOTHO gene variant KL-VS attenuates APOE4-associated β-amyloid (Aβ) accumulation in a late-middle-aged cohort enriched with Alzheimer disease (AD) risk factors.

Methods

Three hundred nine late-middle-aged adults from the Wisconsin Regist...
S-EPMC6550504 | biostudies-literature
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