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TranscriptomicsExpression data from mouse B16-F10 cells exposed to hypoxic conditions in vitro.
Analysis of gene expression profile of B16-F10 murine melanoma cells exposed to hypoxic conditions (1% oxygen) or hypoxia mimicry (cobalt chloride) for 24 hours. Gene expression profiles were analyzed using MG-U74Av2 oligonucleotide microarrays. Data analysis revealed 2541 probesets (FDR<5%) for 1...
ORGANISM(S): Mus musculus 
2011-11-11 | E-GEOD-33607 | biostudies-arrayexpress
TranscriptomicsGenome-wide HSF1 binding sites in control and heat shocked spermatocytes and hepatocytes
In somatic cells elevated temperature induces activation of the heat shock transcription factor 1 (HSF1) what leads to heat shock proteins synthesis and cytoprotection. However, in the male germ cells (spermatocytes) upon HSF1 activation, caspase-3 dependent apoptosis is induced and spermatogenic ce...
ORGANISM(S): Mus musculus 
2012-08-28 | E-GEOD-40390 | biostudies-arrayexpress
TranscriptomicsExpression data from three human cancer cell lines (PC-3, SK-OV-3, WM793B) exposed to experimental cycling and chronic hypoxa in vitro
One of the most important features of tumor microenvironment, imposing adverse effect on patient prognosis, is low oxygen tension. There are two types of hypoxia that may occur within tumor mass: chronic and cycling. Preliminary studies point at cycling hypoxia as being more relevant in induction of...
ORGANISM(S): Homo sapiens 
2013-12-06 | E-GEOD-53012 | biostudies-arrayexpress
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