Sort   by:  
 Page size 
TranscriptomicsThe difference of gene expression in mouse OPCs in normothermic and hypothermic culture
We have found that the cell yield of oligodendrocyte precursor cells (OPCs) are higher in 31.5 degC than in 37 degC not by suppression of apoptosis but by enhancement of proliferation. Here, we performed transcriptome analysis using Affymetrix GeneChip on the primary cultured oligodendrocyte precurs...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-20645 | biostudies-arrayexpress
ProteomicsInvestigation of Oligodendrocyte Precursor Cell Differentiation by Quantitative Proteomics
Oligodendrocytes, the myelinating cells of the central nervous system, are essential for correct brain function. They originate from oligodendrocyte precursor cells (OPCs) through a differentiation process which is only incompletely understood and impaired in a variety of demyelinating diseases. Bet...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-06-21 | PXD012544 | Pride
Quantification Tmt labeling Oligodendrocytes Mass spectrometry Oligodendrocyte precursor cells 
TranscriptomicsAnalysis of gene expression in QKI knockdown CG-4 cells
QKI is required for myelin formation in the verterbrate brain. It functions by binding RNA and regulating its stability, translation, and/or aternative splicing. We have used Affymetrix exon arrays to assess changes in gene expression in response to QKI knockdown on an exon level in rat CG-4 oligod...
ORGANISM(S): Rattus norvegicus 
2011-01-20 | E-GEOD-26716 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of single cells of the oligodendrocyte lineage from nine distinct regions of the anterior-posterior and dorsal-ventral axis of the mouse juvenile central nervous system
5069 transcriptomes of single oligodendrocyte cells from spinal cord, substantia nigra-ventral tegmental area, striatum, amygdala, hypothalamic nuclei, zona incerta, hippocampus, and somatosensory cortex of male and female mice between post-natal day 21 and 90. The study aimed at identifying diverse...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-75330 | biostudies-arrayexpress
GenomicsActivation of the chromatin-remodeling factor Smarca4/Brg1 cooperates with Olig2 to establish oligodendrocyte identity and control CNS myelination [ChIP-seq]
We investigate the role of Brg1 and Olig2 during oligodendrocyte differentiation by combining gene conditional knockout and next generation sequencing technology. We generate genome-wide maps of RNA polymerase II (RPolII), Brg1 (Smarca4), Olig2 and histone modifications in primary rat oligodendrocyt...
ORGANISM(S): Rattus norvegicus 
2013-01-20 | E-GEOD-42447 | biostudies-arrayexpress
GenomicsSingle-cell transcriptomic analysis of human and mouse oligodendrocyte precursor cells
Single-cell transcriptomic analysis of human and mouse oligodendrocyte precursor cells
PRJNA883743 | ENA
GenomicsOligodendrocyte precursor cells facilitate neuronal lysosome release
Oligodendrocyte precursor cells facilitate neuronal lysosome release
PRJNA1207448 | ENA
TranscriptomicsInhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination
We used transcription-profiling to identify mitogen-activated protein kinase (Mapk) signaling as an important regulator involved in the differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes. We show in tissue culture that activation of Mapk signaling by elevation of intrac...
ORGANISM(S): Rattus norvegicus 
2013-08-29 | E-GEOD-50042 | biostudies-arrayexpress
TranscriptomicsExpression profiles of mouse glioma-initiating cells.
To identify factors involved in glioma-initiating cells (GICs), we compared gene expressions between GIC-like cells and non-GICs. p53-deficient Neural stem cells (NSCs), oligodendrocyte precursor cells (OPCs), and astrocytes (ASTs) were transfected with pCMS-EGFP-HRasL61 and pBabe-neo by electropora...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-28091 | biostudies-arrayexpress
ProteomicsChanges in the oligodendrocyte cell progenitor cell proteome with ageing
Following CNS demyelination, adult oligodendrocyte progenitor cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative process called remyelination. While remyelination is very efficient in young adults, its efficiency declines progressively with ageing. Here we perf...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-25 | PXD010383 | Pride
Tandem mass tags Lc-ms Proteome Oligodendrocyte cell progenitor cell 
Sort   by:  
 Page size