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TranscriptomicsThe difference of gene expression in mouse OPCs in normothermic and hypothermic culture
We have found that the cell yield of oligodendrocyte precursor cells (OPCs) are higher in 31.5 degC than in 37 degC not by suppression of apoptosis but by enhancement of proliferation. Here, we performed transcriptome analysis using Affymetrix GeneChip on the primary cultured oligodendrocyte precurs...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-20645 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of single cells of the oligodendrocyte lineage from nine distinct regions of the anterior-posterior and dorsal-ventral axis of the mouse juvenile central nervous system
5069 transcriptomes of single oligodendrocyte cells from spinal cord, substantia nigra-ventral tegmental area, striatum, amygdala, hypothalamic nuclei, zona incerta, hippocampus, and somatosensory cortex of male and female mice between post-natal day 21 and 90. The study aimed at identifying diverse...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-75330 | biostudies-arrayexpress
TranscriptomicsInhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination
We used transcription-profiling to identify mitogen-activated protein kinase (Mapk) signaling as an important regulator involved in the differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes. We show in tissue culture that activation of Mapk signaling by elevation of intrac...
ORGANISM(S): Rattus norvegicus 
2013-08-29 | E-GEOD-50042 | biostudies-arrayexpress
TranscriptomicsMultiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors
This study provides an overview of the transcriptional signature of oligodendrocyte progenitor cells (OPCs) exposed to the CSF collected from multiple sclerosis patients with either a relapsing remitting disease course (RRMS) or a confirmed primary progressive diagnosis (PPMS). Using an Affymetrix ...
ORGANISM(S): Rattus norvegicus 
2015-06-19 | E-GEOD-60881 | biostudies-arrayexpress
UnknownEffects of chronic social stress on oligodendrocyte proliferation-maturation and myelin status in prefrontal cortex and amygdala in adult mice.
Not available
S-EPMC9170777 | biostudies-literature
GenomicsIntegrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival.
Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival.
PRJNA1163390 | ENA
GenomicsPervasive environmental chemicals impair oligodendrocyte development
Pervasive environmental chemicals impair oligodendrocyte development
PRJNA874437 | ENA
UnknownOxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders.
Not available
S-EPMC8195802 | biostudies-literature
UnknownReduced Expression of Oligodendrocyte Linage-Enriched Transcripts During the Endoplasmic Reticulum Stress/Integrated Stress Response.
Not available
S-EPMC11262469 | biostudies-literature
UnknownInsights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response.
Not available
S-EPMC9900777 | biostudies-literature
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