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UnknownThe HIV type 1 epidemic in Bulgaria involves multiple subtypes and is sustained by continuous viral inflow from West and East European countries.
Little is known about the HIV-1 epidemic in Balkan countries. To fill the gap, we investigated the viral genetic diversity in Bulgaria, by sequencing and phylogenetic characterization of 86 plasma samples collected between 2002 and 2006 from seropositive individuals diagnosed within 1986-2006. Analy...
S-EPMC2927039 | biostudies-literature
TranscriptomicsToxicogenomic analysis of rural and urban air particles
Atmospheric particulate matter (PM) is a recognized risk factor for the global burden of disease in human populations. We are presenting here the application of toxicogenomics in the evaluation of the toxic effects of organic content of atmospheric particle matter (PM), from urban and rural environm...
ORGANISM(S): Danio rerio 
2015-10-26 | E-GEOD-53522 | biostudies-arrayexpress
UnknownPatient-physician discordance in assessment of adherence to inhaled controller medication: a cross-sectional analysis of two cohorts.
OBJECTIVE:We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance. DESIGN:Baseline data from two prospective multicentre observational studies. SETTING:29 allergy, pulmonology and paediatric secondary care outp...
S-EPMC6858182 | biostudies-literature
UnknownEfficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis: a protocol for a multicentre, randomised, parallel three arms, active-controlled, phase III open label with blinded outcome assessment study.

Introduction

Non-infectious uveitis include a heterogeneous group of sight-threatening and incapacitating conditions. Their correct management sometimes requires the use of immunosuppressive drugs (ISDs), prescribed in monotherapy or in combination. Several observational studies showed that ...
S-EPMC8943738 | biostudies-literature
UnknownPopulation structure in Quercus suber L. revealed by nuclear microsatellite markers.
Quercus suber L. is a sclerophyllous tree species native to the western Mediterranean, a region that is considered highly vulnerable to increased temperatures and severe dry conditions due to environmental changes. Understanding the population structure and demographics of Q. suber is ...
S-EPMC9206845 | biostudies-literature
UnknownA Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of Clostridioides difficile Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response.

Background

Exposure to antibiotics predisposes to dysbiosis and Clostridioides difficile infection (CDI) that can be severe, recurrent (rCDI), and life-threatening. Nonselective drugs that treat CDI and perpetuate dysbiosis are associated with rCDI, in part due to loss of microbiome-derived ...
S-EPMC11175683 | biostudies-literature
UnknownTrust in government moderates the association between fear of COVID-19 as well as empathic concern and preventive behaviour.
With the COVID-19 pandemic, behavioural scientists aimed to illuminate reasons why people comply with (or not) large-scale cooperative activities. Here we investigated the motives that underlie support for COVID-19 preventive behaviours in a sample of 12,758 individuals from 34 countries. We hypothe...
S-EPMC11332001 | biostudies-literature
UnknownA multi-institutional meningioma MRI dataset for automated multi-sequence image segmentation.
Meningiomas are the most common primary intracranial tumors and can be associated with significant morbidity and mortality. Radiologists, neurosurgeons, neuro-oncologists, and radiation oncologists rely on brain MRI for diagnosis, treatment planning, and longitudinal treatment monitoring. However, a...
S-EPMC11096318 | biostudies-literature
UnknownSearch for supersymmetry in pp collisions at [Formula: see text] TeV in events with a single lepton, jets, and missing transverse momentum.
Results are reported from a search for new physics processes in events containing a single isolated high-transverse-momentum lepton (electron or muon), energetic jets, and large missing transverse momentum. The analysis is based on a 4.98 fb-1 sample of proton-proton collisions at a cente...
S-EPMC4370766 | biostudies-literature
UnknownRevisiting the phylogeography and demography of European badgers (Meles meles) based on broad sampling, multiple markers and simulations.
Although the phylogeography of European mammals has been extensively investigated since the 1990s, many studies were limited in terms of sampling distribution, the number of molecular markers used and the analytical techniques employed, frequently leading to incomplete postglacial recolonisation sce...
S-EPMC4220720 | biostudies-literature
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