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ProteomicsEffect of Nop53 depletion on the exosome interactome
In order to evaluate how Nop53 modulates the interaction of Rrp6 and Rrp43 with other factors, a coimmunoprecipitation assay was performed both in the presence (-doxicycline) and upon depletion (+ doxicycline) of Nop53 using the condional strain Δnop53/tetOff::GFP-NOP53 carrying the Rrp6-TAP or Rrp4...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-08 | PXD014187 | Pride
Nop53 Rrna processing Rna exosome Ribosome biogenesis 
ProteomicsEffect of Nop53 depletion on the compositional changes during pre-60S maturation
The eukaryotic ribosome biogenesis is a highly orchestrated multistep process that starts at the nucleolus with the transcription of pre-rRNAs 5S and 35S. The latter comprises the mature 18S, 5.8S and 25S rRNAs separated by internal transcribed spacers (ITS1 and ITS2) and externally flanked by the 5...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-09 | PXD023383 | Pride
Nop53 Eukaryotic ribosome biogenesis Pre-60s S. cerevisiae 
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (Nucleoli TMT)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-12 | MSV000090518 | MassIVE
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (Chromatin MudPIT data)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-11 | MSV000090511 | MassIVE
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (CLASP MudPIT data)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-12 | MSV000090516 | MassIVE
UnknownKetamine, Etomidate, and Mortality in Emergency Department Intubations.

Importance

The choice of induction agent during rapid sequence intubation (RSI) of critically ill adults may affect clinical outcomes. Although ketamine and etomidate are frequently used for RSI, their comparative effectiveness remains controversial.

Objective

To compare the safety of...
S-EPMC12706683 | biostudies-literature
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