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GenomicsNatural variation of histone modification and its impact on gene expression in rat
Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. To begin to understand the impact of natural variation on histone methylation levels we generated and quantified large-scale ...
ORGANISM(S): Rattus norvegicus 
2012-05-30 | E-MTAB-1102 | biostudies-arrayexpress
TranscriptomicsTP53 and TP63 modulation of Squamous PDAC
Based on the association of TP53 mutation and upregulated TP63 expression in the squamous subtype, we used cell lines derived from genetically engineered mouse models of PDAC (KRAS Trp53fl/+ and KRAS Trp53fl/+ Trp63fl/fl) to begin to unravel the functional consequences of these events in defining sq...
ORGANISM(S): Mus musculus 
2016-03-03 | E-MTAB-4415 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of head tissue from Drosophila melanogaster
We sequenced mRNA from head tissue of females and male of Drosophila melanogaster to identify genes differentially expressed between the sexes and sex-specific alternative splicing events. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/...
ORGANISM(S): Drosophila melanogaster 
2010-04-08 | E-GEOD-20348 | biostudies-arrayexpress
TranscriptomicsRNA-Seq on Illumina platform of Drosophila DrosDel deficiency lines
RNA-Seq reads of DrosDel deficiency (Df/+) and parental strain diploid flies along with spike-in controls was performed on the Illumina platform. Samples are named in this dataset according to the following sample naming scheme: tissue_genotype shorthand_sex_biological replicate #_platform. We seque...
ORGANISM(S): Drosophila melanogaster 
2012-04-03 | E-GEOD-31549 | biostudies-arrayexpress
TranscriptomicsA spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche - Visium
Multiple distinct cell types of the human lung and airways have been defined by single cell RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define novel cell types which we map back into the macro- and micro-anatomical tissue context to define functional tissue microen...
ORGANISM(S): Homo sapiens 
2022-01-06 | E-MTAB-11640 | biostudies-arrayexpress
TranscriptomicsExpression in Aneuploid Drosophila S2 Cells
Chromosomal and segmental aneuploidies are usually lethal or common features of cancer cells and variety of disease, but little is known about how copy number relates to gene expression. Drosophila males have a single X chromosome and two sets of autosomes, but X chromosome and autosome transcripts ...
ORGANISM(S): Drosophila melanogaster 
2010-01-11 | E-GEOD-16344 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of head tissue from Doa and fne mutants, Drosophila melanogaster.
Transcriptional profiling of head tissue of Drosophila Darkener of apricot (Doa) and found in neurons (fne) mutants was performed by RNA-SEQ in females and males. The transcriptional and post-transcriptional targets of these genes, which are involved in regulation by several processes including spli...
ORGANISM(S): Drosophila melanogaster 
2014-03-13 | E-GEOD-37811 | biostudies-arrayexpress
UnknownUnderstanding the impact of the COVID-19 pandemic response on GI infection surveillance trends in England, January 2020-April 2022.
Not available
S-EPMC10540168 | biostudies-literature
UnknownAppropriateness of Medications in Older Adults Living With Frailty: Impact of a Pharmacist-Led Structured Medication Review Process in Primary Care.
Not available
S-EPMC6900606 | biostudies-literature
UnknownSexual assault: women's voices on the health impacts of not being believed by police.
Not available
S-EPMC8141152 | biostudies-literature
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