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GenomicsDNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID
Changes in DNA methylation are required for the formation of germinal centers (GC), but the mechanisms of such changes are poorly understood. Activation-induced cytidine deaminase (AID) has been recently implicated recently in DNA demethylation through its deaminase activity coupled with DNA repai...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-71702 | biostudies-arrayexpress
Transcriptomicsarray-CGH profiling of human neuroblastoma samples obtained from infants included in the INES99.1, INES99.2 and INES99.3 trials
In neuroblastoma (NB), the presence of segmental chromosome alterations (SCA) is associated with a higher risk of relapse, even when occurring together with numerical chromosome alterations (NCA). Furthermore, recent evidence shows that SCAs play a role in tumor progression. In order to analyze the ...
ORGANISM(S): Homo sapiens 
2011-12-07 | E-GEOD-26494 | biostudies-arrayexpress
TranscriptomicsGenotyping of human neuroblastic tumor NB99
The genetic aberrations of NB tumor NB99 were determined using the Affymetrix SNP chip 50K array (Hind III). Experiment Overall Design: DNA copy number change of NB tumor NB99
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12461 | biostudies-arrayexpress
TranscriptomicsDNA Methyltransferase 1 and DNA Methylation Patterning Contribute to Germinal Center B-Cell Differentiation
We performed DNA methylation (HELP) and gene expression profiling in 17 samples of purified Germinal center B cells (GCBs) and Naive B cells (NBC). We performed supervised analysis using HELP data and defined DNA methylation signature differentiting 2 subgroups of B cvells. Study included purifica...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31671 | biostudies-arrayexpress
TranscriptomicsDNA methylation signatures define molecular subtypes of Diffuse Large B Cell Lymphoma
We performed DNA methylation (HELP) and gene expression profiling in 69 samples of diffuse large B cell lymphoma (DLBCL). First, by gene expression, two molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL were assigned to the 69 DLBCL cases. ...
ORGANISM(S): Homo sapiens 
2010-09-03 | E-GEOD-23967 | biostudies-arrayexpress
UnknownIn vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.
Not available
S-EPMC2542654 | biostudies-literature
TranscriptomicsscRNAseq dataset from neuroblastomas tumoroids
Neuroblastoma (NB), a pediatric cancer arising from disrupted sympathetic neuron differentiation, exhibits marked heterogeneity and limited therapeutic options. To better understand its molecular circuitry dynamics, we applied CARDAMOM, a novel Gene Regulatory Network (GRN) inference framework to s...
ORGANISM(S): Homo sapiens 
2026-07-07 | E-MTAB-16741 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiles of TAE-684 treated or shALK transfected neuroblastoma cell lines
Human wild-type ALK (SK-N-AS, NGP, IMR-32), ALKR1275Q (CLB-GA, LAN-5, UKF-NB-3), ALKF1174L (SK-N-SH, Kelly, SMS-KCNR) and ALK amplified (NB-1) neuroblastoma cell lines were treated in triplicate with 0.3M-k_M NPV-TAE-684 (Novartis/SelleckChem) or DMSO (VWR) for 6 hours, followed by RNA isolation and...
ORGANISM(S): Homo Sapiens 
2015-05-04 | E-MTAB-3205 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiles of SK-N-AS neuroblastoma cells with induced ALK-wt, ALK-F1174L or ALK-R1275Q
Establishment of inducible SK-N-AS ALKwt, ALKF1174L and ALKR1275Q cell lines Human neuroblastoma SK-N-AS cells were electroporated with pcDNA6/TR (Invitrogen) using the NeonM-eM-( Transfection System (Life Techologies). Single cell clones were generated using blasticidin (7.5M-eM-5g/ml) and limited ...
ORGANISM(S): homo sapiens 
2015-05-04 | E-MTAB-3207 | biostudies-arrayexpress
TranscriptomicsTranscript profiling in Actinobacillus pleuropneumoniae after adherence to, or planktonic growth over, SJPL cells.
Host-pathogen interactions are of great importance in understanding the pathogenesis of infectious microorganisms. We developed in vitro models to study porcine respiratory tract pathogens using an immortalized epithelial cell line, the St. Jude Porcine Lung (SJPL) cell line. In conditions where cy...
ORGANISM(S): Actinobacillus pleuropneumoniae 
2008-07-09 | E-GEOD-12009 | biostudies-arrayexpress
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