Sort   by:  
 Page size 
TranscriptomicsPyrococcus furiosus crRNAs associated with Cmr, Csa and Cst CRISPR-Cas systems
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally div...
ORGANISM(S): Pyrococcus furiosus 
2015-07-10 | E-GEOD-65781 | biostudies-arrayexpress
MetabolomicsGlycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
Central carbon metabolism is highly conserved across microbial species, but can catalyze very different pathways depending on the organism and their ecological niche. Here, we study the dynamic reorganization of central metabolism after switches between the two major opposing pathway configurations ...
2022-01-11 | MTBLS3887 | MetaboLights
TranscriptomicsHDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38237 | biostudies-arrayexpress
TranscriptomicsGene expression data from cortex of 9 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38218 | biostudies-arrayexpress
TranscriptomicsGene expression data from cortex of 15 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38219 | biostudies-arrayexpress
GenomicsApplication of Microdroplet PCR for Large-Scale Targeted Bisulfite Sequencing
Cytosine methylation of DNA CpG dinucleotides in gene promoters is an epigenetic modification that regulates gene transcription. While many methods exist to interrogate methylation states, no current methods offer large-scale, targeted, single CpG resolution. We report an approach combining bisulf...
ORGANISM(S): Homo sapiens 
2011-06-25 | E-GEOD-30179 | biostudies-arrayexpress
UnknownDiagnostic potential of the NMDA receptor peptide assay for acute ischemic stroke.
Not available
S-EPMC3407099 | biostudies-literature
UnknownFamilial Parkinson's point mutation abolishes multiple system atrophy prion replication.
Not available
S-EPMC5777081 | biostudies-literature
UnknownRepurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia.
Not available
S-EPMC9121309 | biostudies-literature
UnknownTissue-Specific Distribution of Eggs in The Definitive Host Drives Transcriptomic and Behavioral Differences in <i>Schistosoma Mansoni</i> Miracidia.
Not available
S-EPMC12393456 | biostudies-literature
Sort   by:  
 Page size